DKKL1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse testis tissue lysate, Primary antibody: P00332(DKKL1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    

  
  

The DKKL1 (Dickkopf-like protein 1) antibody is a tool used to study the DKKL1 protein, a member of the Dickkopf (DKK) family. Unlike other DKK proteins that primarily modulate Wnt signaling by binding to LRP5/6 co-receptors, DKKL1 shares structural homology but exhibits distinct functional roles. It is a glycosylphosphatidylinositol (GPI)-anchored protein encoded by the *DKKL1* gene, predominantly expressed in germ cells during spermatogenesis, with roles in testicular development and male fertility. Emerging studies also suggest its involvement in neurodevelopment and immune regulation.

DKKL1 antibodies are essential for detecting protein localization and expression in tissues (e.g., testis, brain) via techniques like Western blot, immunohistochemistry, or immunofluorescence. These antibodies help investigate DKKL1’s physiological and pathological roles, including its potential links to infertility, neurodegenerative disorders, or cancer. However, challenges persist due to the protein’s low abundance and homology with other DKK members, requiring rigorous validation of antibody specificity (e.g., using knockout controls).

Current research focuses on clarifying DKKL1’s signaling mechanisms, as its interactions remain less defined compared to canonical DKK proteins. Reliable antibodies are critical for advancing studies in reproductive biology, neuroscience, and disease biomarker discovery.