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CNTFR抗体

Rabbit Polyclonal CNTFR Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期:2025-05-11

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称:
CNTFR抗体
英文名称:
Rabbit Polyclonal CNTFR Antibody
品牌:
艾普蒂
产地:
武汉
保存条件:
Stored at -20°C for 1651 year. Avoid repeated freeze / thaw cycles.
产品类别:
抗体
重组:
应用:
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性:
Human,Mouse,Rat
宿主:
Rabbit
偶联物:
靶点:
CNTFR

验证与应用

应用及物种
WB1/500-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human CNTFR
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: HT29 and Hela cell lysate, Primary antibody: P00283(CNTFR Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P00283(CNTFR Antibody) at dilution 1/130. (Original magnification: ×200)    


           

参考文献

以下是基于真实文献的示例,但由于CNTFR抗体相关研究较为专业且分散,以下内容为模拟参考格式(具体文献需通过数据库验证):

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1. **文献名称**: *Characterization of a monoclonal antibody specific to the ciliary neurotrophic factor receptor α (CNTFRα)*

**作者**: Davis, S., et al.

**摘要**: 本研究报道了一种针对CNTFRα亚基的单克隆抗体的开发与验证。通过免疫印迹(Western blot)和免疫组化(IHC)证实该抗体能特异性识别小鼠及人类组织中的CNTFRα,并用于探究其在神经系统中的表达分布。

2. **文献名称**: *CNTFR signaling in motor neuron survival and disease*

**作者**: Robinson, M.B., & Lee, J.K.

**摘要**: 文章利用抗CNTFR抗体在肌萎缩侧索硬化症(ALS)模型中研究受体表达变化,发现CNTFR在疾病早期下调,提示其可能作为神经保护治疗的潜在靶点。

3. **文献名称**: *Localization of CNTFR in the developing rat brain using immunohistochemistry*

**作者**: Zhang, Y., et al.

**摘要**: 通过特异性抗体标记,揭示了CNTFR在胚胎期大鼠脑部特定区域(如海马和皮层)的动态表达模式,支持其在神经发育中的调控作用。

4. **文献名称**: *Cross-species reactivity of anti-CNTFR antibodies: Implications for preclinical studies*

**作者**: Tanaka, T., & Hirano, A.

**摘要**: 评估了多种商业CNTFR抗体在人类、小鼠和大鼠样本中的交叉反应性,为跨物种研究提供实验依据,并指出部分抗体存在种属特异性差异。

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**建议**:如需真实文献,可检索PubMed(https://pubmed.ncbi.nlm.nih.gov/)或Google Scholar,关键词组合如 **"CNTFR antibody" + "validation"** 或 **"anti-CNTFR" + application**,筛选近10年高引论文。部分经典研究可能集中于1990-2000年代。

       

背景信息

**Background of CNTFR Antibody**

The ciliary neurotrophic factor receptor (CNTFR) is a key component of the CNTF signaling pathway, which plays critical roles in neuronal survival, differentiation, and regeneration. CNTFR is a multi-subunit receptor complex comprising CNTFRα, leukemia inhibitory factor receptor β (LIFRβ), and glycoprotein 130 (gp130). Unlike typical cytokine receptors, CNTFRα lacks transmembrane and intracellular domains, anchoring to the cell membrane via a glycosylphosphatidylinositol (GPI) linkage. CNTFR is highly expressed in the nervous system, skeletal muscle, and immune cells, where it mediates neuroprotective effects and regulates energy homeostasis.

Antibodies targeting CNTFR are essential tools for studying its expression, localization, and function. They enable detection of CNTFRα in tissues or cells via techniques like Western blot, immunohistochemistry, or flow cytometry. Researchers also use CNTFR-neutralizing antibodies to dissect signaling mechanisms, particularly in models of neurodegenerative diseases (e.g., amyotrophic lateral sclerosis) or metabolic disorders. Commercial CNTFR antibodies are typically validated for specificity against human, mouse, or rat isoforms, aiding translational research.

Recent studies highlight CNTFR's therapeutic potential, driving demand for reliable antibodies to explore its role in neuroregeneration, muscle repair, and metabolic regulation. However, challenges remain in distinguishing CNTFRα from related receptors due to structural similarities, emphasizing the need for highly specific antibodies in experimental designs.

       
CNTFR抗体;CNTFR;CNTFR Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ¥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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