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  • KIR3DL1抗体
  • KIR3DL1抗体

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KIR3DL1抗体

Mouse Monoclonal KIR3DL1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
KIR3DL1抗体
英文名称：
Mouse Monoclonal KIR3DL1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1035 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
KIR3DL1

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesKIR; NKB1; NKAT3; NKB1B; NKAT-3; CD158E1; KIR3DL1/S1
Entrez GeneID3811
clone6D9A4
WB Predicted band size49kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenPurified recombinant fragment of human KIR3DL1 (AA: extra 22-340) expressed in HEK293 cells.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using KIR3DL1 mouse mAb against A431 (1), Raji (2), SPC-A-1 (3), K562 (4), HEK293 (5), U937 (6), and C6 (7) cell lysate.    


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       Flow cytometric analysis of Jurkat cells using KIR3DL1 mouse mAb (green) and negative control (red).    


           

参考文献

以下是3条关于KIR3DL1抗体的模拟参考文献示例(实际文献需通过学术数据库查询)：

1. **文献名称**：*"Anti-KIR3DL1 monoclonal antibody enhances NK cell-mediated cytotoxicity in HLA-Bw4-positive cancers"*

**作者**：Smith A, et al.

**摘要**：研究开发了一种靶向KIR3DL1的单克隆抗体，通过阻断KIR3DL1与HLA-Bw4的相互作用，增强自然杀伤(NK)细胞对表达HLA-Bw4的肿瘤细胞的杀伤活性，为癌症免疫治疗提供新策略。

2. **文献名称**：*"KIR3DL1 genetic diversity and antibody-based detection in autoimmune disorders"*

**作者**：Chen L, et al.

**摘要**：探讨了KIR3DL1基因多态性与自身免疫疾病(如类风湿关节炎)的关联，并验证了一种高特异性抗体用于检测患者外周血中KIR3DL1蛋白的表达水平及其临床意义。

3. **文献名称**：*"Structural basis of KIR3DL1 recognition by therapeutic antibodies for HIV control"*

**作者**：Johnson R, et al.

**摘要**：通过冷冻电镜解析了KIR3DL1与两种治疗性抗体的复合物结构，揭示抗体通过结合KIR3DL1的D0结构域抑制其功能，可能增强NK细胞清除HIV感染细胞的能力。

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**注**：以上为模拟内容，实际文献请通过PubMed、Web of Science等平台检索关键词(如“KIR3DL1 antibody”、“KIR3DL1 therapeutic”)。

       

背景信息

KIR3DL1 is a member of the killer cell immunoglobulin-like receptor (KIR) family, primarily expressed on natural killer (NK) cells and certain T-cell subsets. As an inhibitory receptor, it plays a critical role in regulating NK cell-mediated immune responses by interacting with specific human leukocyte antigen (HLA) class I molecules, particularly HLA-Bw4 epitopes. This interaction delivers inhibitory signals to prevent NK cell activation, ensuring immune tolerance to healthy cells while enabling targeted cytotoxicity against infected or malignant cells lacking HLA expression.

The KIR3DL1 gene exhibits extensive polymorphism, with over 100 alleles identified, contributing to diverse receptor expression levels and functional variations across populations. This genetic diversity influences susceptibility to diseases and clinical outcomes. For instance, specific KIR3DL1/HLA-B combinations are associated with delayed HIV progression, control of viral infections, and altered risks for autoimmune disorders and cancers. In hematopoietic stem cell transplantation, KIR3DL1-ligand mismatching may enhance graft-versus-leukemia effects but also increase graft-versus-host disease risks.

Antibodies targeting KIR3DL1 have been developed to modulate NK cell activity for therapeutic purposes. Blocking these inhibitory receptors can enhance NK-mediated tumor cell lysis, offering potential in cancer immunotherapy. Conversely, agonist antibodies may suppress excessive NK activation in autoimmune conditions. Research continues to explore their clinical applications, balancing efficacy with immune-related adverse effects.

       
KIR3DL1抗体;KIR3DL1;KIR3DL1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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