CD209抗体

CD209. also known as DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin), is a C-type lectin receptor predominantly expressed on the surface of dendritic cells and macrophages. It plays a critical role in pathogen recognition, cell-cell interactions, and immune modulation by binding to high-mannose glycans on viral, bacterial, and fungal surfaces. CD209 antibodies are essential tools for studying its function in infectious diseases (e.g., HIV, Ebola, dengue), cancer immunology, and autoimmune disorders. These antibodies enable detection of CD209 expression in tissues or cells, block ligand-receptor interactions, or modulate immune responses. Research highlights its dual role: promoting pathogen uptake for immune surveillance while being exploited by pathogens for immune evasion. CD209-targeting therapies, including antibody-based strategies, are explored for vaccine development and immunotherapies. Structural studies reveal its carbohydrate-recognition domain (CRD) and cytoplasmic tail as key functional regions. Antibody specificity varies, with some recognizing conserved epitopes across species, aiding translational research. Challenges include understanding context-dependent signaling and avoiding off-target effects in therapeutic applications.