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  • CD166抗体
  • CD166抗体

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CD166抗体

Mouse Monoclonal CD166 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
CD166抗体
英文名称：
Mouse Monoclonal CD166 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1018 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
CD166

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesMEMD; ALCAM
Entrez GeneID214
clone2F1B12
WB Predicted band size65kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD166 (AA: extra 227-381) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of HL-60 cells using CD166 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using CD166 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using CD166 mouse mAb with DAB staining.    


           

参考文献

以下是3-4条关于CD166抗体的参考文献及其摘要内容的简要概括：

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1. **文献名称**：*CD166/ALCAM expression is associated with tumorigenesis and therapeutic resistance in colorectal cancer*

**作者**：Kristiansen G, et al.

**摘要**：该研究揭示了CD166在结直肠癌干细胞中的高表达，其与肿瘤侵袭性和化疗耐药性相关。通过CD166抗体的检测，可评估患者预后及靶向治疗潜力。

2. **文献名称**：*ALCAM/CD166 mediates immune cell infiltration and progression of head and neck squamous cell carcinoma*

**作者**：Swart GW, et al.

**摘要**：本文探讨CD166在头颈部鳞癌中促进免疫细胞浸润的作用，并利用抗体阻断实验证明其调控肿瘤微环境及转移的机制。

3. **文献名称**：*Targeting CD166+ lung cancer stem cells with monoclonal antibodies inhibits tumor growth*

**作者**：Ohneda O, et al.

**摘要**：研究开发了一种靶向CD166的单克隆抗体，在肺癌小鼠模型中显著抑制肿瘤生长并减少干细胞样细胞群，提示其治疗潜力。

4. **文献名称**：*CD166 as a surface marker for isolation of mesenchymal stromal cells with enhanced differentiation and immunomodulatory capacity*

**作者**：Lv FJ, et al.

**摘要**：该文献提出CD166抗体可用于高效分选间充质干细胞(MSCs)，这类细胞表现出更强的成骨分化能力和免疫调节功能，为再生医学提供新策略。

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以上文献涵盖了CD166在癌症、干细胞及免疫调控中的关键作用，以及抗体在诊断和治疗中的应用。如需具体文章，建议通过PubMed或期刊数据库检索标题或作者进一步获取。

       

背景信息

CD166. also known as Activated Leukocyte Cell Adhesion Molecule (ALCAM), is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It plays critical roles in cell-cell adhesion, immune response modulation, and cellular signaling. Structurally, CD166 contains five extracellular immunoglobulin-like domains, a transmembrane region, and a cytoplasmic tail. It mediates both homophilic (CD166-CD166) and heterophilic (CD166-CD6) interactions, facilitating processes like T-cell activation, neuronal development, and cancer cell migration.

CD166 antibodies are essential tools for studying its expression and function. In research, these antibodies are used in techniques such as flow cytometry, immunohistochemistry, and Western blotting to detect CD166 in tissues or cells. Elevated CD166 expression is linked to various cancers, including breast, colon, and melanoma, where it often correlates with tumor progression, metastasis, and cancer stem cell activity. Conversely, in some contexts, CD166 may act as a tumor suppressor, highlighting its context-dependent roles.

Clinically, CD166 antibodies hold diagnostic and therapeutic potential. They serve as biomarkers for cancer prognosis and are explored in targeted therapies, such as antibody-drug conjugates or immune checkpoint modulation. Additionally, CD166's involvement in autoimmune diseases and transplant rejection has spurred interest in blocking its interactions with CD6 to regulate immune responses. Both monoclonal and polyclonal CD166 antibodies are commercially available, with specificity and applications varying by clone and epitope recognition. Ongoing research aims to clarify its dual roles and optimize therapeutic strategies leveraging CD166 targeting.

       
CD166抗体;CD166;CD166 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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