基本信息 产品详情 公司简介 推荐产品
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
网站主页 化工产品目录 生物化工 抗体 P2RY14 antibody P2RY14抗体
  • P2RY14抗体
  • P2RY14抗体
  • P2RY14抗体

1/3

P2RY14抗体

Mouse Monoclonal P2RY14 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
P2RY14抗体
英文名称：
Mouse Monoclonal P2RY14 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1014 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
P2RY14

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesP2Y14; BPR105; GPR105
Entrez GeneID9934
clone5A3F1
WB Predicted band size39kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human P2RY14 (AA: extra mix) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

  •  

     

       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


  •  

     

       Immunofluorescence analysis of Hela cells using P2RY14 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


  •  

     

       Flow cytometric analysis of Hela cells using P2RY14 mouse mAb (green) and negative control (red).    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using P2RY14 mouse mAb with DAB staining.    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using P2RY14 mouse mAb with DAB staining.    


           

参考文献

以下是关于P2RY14抗体的3篇模拟参考文献示例(注：内容为虚构，仅用于格式参考)：

---

1. **文献名称**：*P2RY14 Antibody-Based Detection of Receptor Overexpression in Inflammatory Bowel Disease*

**作者**：Chen L, et al.

**摘要**：本研究开发了一种高特异性P2RY14抗体，用于检测炎症性肠病(IBD)患者肠道组织中P2RY14的表达水平。结果显示，P2RY14在IBD患者的巨噬细胞和上皮细胞中显著上调，提示其可能通过调节嘌呤信号通路参与黏膜炎症反应。

---

2. **文献名称**：*Targeting P2RY14 with Neutralizing Antibodies Attenuates Cancer-Associated Fibrosis*

**作者**：Gomez-Ramos A, et al.

**摘要**：通过筛选单克隆抗体库，研究者鉴定出能够阻断P2RY14与尿苷二磷酸葡萄糖(UDP-glucose)结合的抗体。实验表明，该抗体可抑制肿瘤微环境中成纤维细胞的活化，减少胰腺癌模型中的纤维化进展。

---

3. **文献名称**：*P2RY14 Antibody Reveals Sex-Specific Expression in Metabolic Syndrome*

**作者**：Kato S, et al.

**摘要**：利用新型P2RY14抗体进行组织染色，发现代谢综合征小鼠的脂肪组织中P2RY14表达存在性别差异。雌性小鼠的受体表达与胰岛素抵抗呈负相关，提示其可能参与性别特异性代谢调控。

---

(注：以上文献为示例性内容，实际研究中需引用真实发表文献。)

       

背景信息

The P2RY14 antibody is designed to target the P2Y14 receptor, a G protein-coupled receptor (GPCR) belonging to the purinergic receptor family. P2Y14 is activated by extracellular UDP-glucose and related nucleotide sugars, distinguishing it from other P2Y receptors that primarily bind nucleotides like ATP or ADP. This receptor plays a role in modulating immune responses, inflammation, and metabolic processes, with expression observed in immune cells (e.g., mast cells, dendritic cells), the nervous system, and certain epithelial tissues. Research highlights its involvement in diseases such as asthma, diabetes, and cancer, where it may regulate cell migration, cytokine release, or tumor progression.

P2RY14 antibodies are critical tools for detecting receptor expression, localization, and functional studies. They enable applications like Western blotting, immunohistochemistry, and flow cytometry to explore P2Y14's physiological and pathological roles. Challenges include low receptor abundance in tissues and potential cross-reactivity with other proteins, necessitating rigorous validation. Recent studies also investigate P2Y14 as a therapeutic target, driving interest in developing agonists/antagonists. However, its signaling mechanisms and disease-specific contributions remain incompletely understood, underscoring the need for high-quality antibodies to advance research in immunology, oncology, and drug discovery.

       
P2RY14抗体;P2RY14;P2RY14 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

P2RY14抗体相关厂家报价

内容声明
official 进入官方账号
拨打电话 立即询价