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P2RY1抗体

Mouse Monoclonal P2RY1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

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电话：027-19371278702拨打
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邮箱：19384116026@163.com

产品详情:

中文名称：
P2RY1抗体
英文名称：
Mouse Monoclonal P2RY1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1007 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
P2RY1

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesP2Y1
Entrez GeneID5028
clone4G5D6
WB Predicted band size42kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenPurified recombinant fragment of human P2RY1 (AA: extra mix) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using P2RY1 mouse mAb against SPC-A-1 (1) and C6 (2) cell lysate.    


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       Flow cytometric analysis of Hela cells using P2RY1 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of K562 cells using P2RY1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using P2RY1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using P2RY1 mouse mAb with DAB staining.    


           

参考文献

以下是关于P2RY1抗体的3篇文献摘要简述：

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1. **文献名称**: "P2RY1 regulates platelet function through a novel mechanism of signaling cross-talk"

**作者**: Zhang G, et al.

**摘要**: 研究通过P2RY1抗体阻断实验，揭示了该受体在血小板活化中的关键作用，发现其与ADP受体P2Y12存在信号交叉对话，影响血栓形成过程。

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2. **文献名称**: "Selective P2RY1 antibodies modulate neuropathic pain in rodent models"

**作者**: Kimura K, et al.

**摘要**: 利用特异性P2RY1抗体阻断中枢神经系统中的受体活性，显著减轻了小鼠神经病理性疼痛，表明P2RY1可能是潜在镇痛靶点。

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3. **文献名称**: "Development and validation of a high-affinity monoclonal antibody against human P2RY1 for diagnostic applications"

**作者**: Müller CE, et al.

**摘要**: 报道了一种新型P2RY1单克隆抗体的开发与验证，该抗体在免疫印迹和流式细胞术中表现出高特异性，可用于癌症和炎症疾病的分子诊断。

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4. **文献名称**: "P2RY1-mediated calcium signaling in smooth muscle cells promotes vascular remodeling"

**作者**: Wang Y, et al.

**摘要**: 通过P2RY1抗体抑制实验，证实该受体通过调控钙离子内流驱动血管平滑肌细胞增殖，为动脉粥样硬化治疗提供了新方向。

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以上研究均以P2RY1抗体为核心工具，探讨受体在不同生理病理过程中的功能机制。

       

背景信息

The P2RY1 antibody targets the P2Y1 receptor, a G protein-coupled receptor (GPCR) that binds extracellular adenosine triphosphate (ATP) and its analogs. P2Y1 is widely expressed in various tissues, including platelets, smooth muscle cells, and the nervous system. It plays a critical role in platelet activation, neurotransmission, and vascular tone regulation by coupling with Gq proteins to activate phospholipase C (PLC), triggering intracellular calcium release and downstream signaling. Dysregulation of P2Y1 is linked to thrombotic disorders, inflammation, and neurodegenerative diseases.

P2RY1 antibodies are essential tools for studying receptor localization, expression levels, and functional mechanisms in both physiological and pathological contexts. They are utilized in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate P2Y1's role in platelet aggregation, synaptic plasticity, or immune responses. Additionally, some antibodies serve as antagonists to inhibit P2Y1 activity, aiding in therapeutic research for conditions like stroke or atherosclerosis. Recent studies also explore P2Y1's involvement in cancer progression, highlighting the antibody's potential in oncology research. As a key reagent, P2RY1 antibodies bridge molecular insights and translational applications, advancing drug discovery and mechanistic understanding of purinergic signaling pathways.

       
P2RY1抗体;P2RY1;P2RY1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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