BCL6抗体

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Immunofluorescence analysis of Hela cells using BCL6 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    

  
  

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     Flow cytometric analysis of K562 cells using BCL6 mouse mAb (green) and negative control (red).    

  
  

BCL6 (B-cell lymphoma 6) antibody is a critical tool in studying the BCL6 protein, a transcriptional repressor encoded by the *BCL6* gene located on chromosome 3q27. Primarily expressed in germinal center B-cells, BCL6 regulates lymphocyte differentiation, apoptosis, and immune responses by suppressing genes involved in DNA damage sensing, cell cycle arrest, and inflammatory signaling. Its dysregulation is strongly associated with B-cell malignancies, particularly diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma, where chromosomal translocations or mutations lead to constitutive BCL6 overexpression, promoting oncogenesis.

BCL6 antibodies are widely used in research and diagnostics to detect BCL6 protein expression via immunohistochemistry (IHC), Western blotting, or flow cytometry. In clinical pathology, BCL6 immunostaining helps classify lymphomas and assess germinal center origin, aiding differential diagnosis. Researchers also employ these antibodies to investigate BCL6's role in normal immune function, lymphoid development, and tumorigenesis. Additionally, BCL6-targeted therapeutic strategies, such as small-molecule inhibitors disrupting BCL6-corepressor interactions, are under exploration, making BCL6 antibodies vital for validating target engagement in preclinical studies. Overall, BCL6 antibodies serve as both diagnostic biomarkers and essential reagents for unraveling BCL6's complex roles in immunity and cancer.