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CD100抗体

Mouse Monoclonal CD100 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

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电话：027-19371278702拨打
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邮箱：19384116026@163.com

产品详情:

中文名称：
CD100抗体
英文名称：
Mouse Monoclonal CD100 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1005 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
CD100

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesSEMA4D; SEMAJ; coll-4; C9orf164; M-sema-G
Entrez GeneID10507
clone5H6E3
WB Predicted band size96.2kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD100 (AA: extra 590-734) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of K562 cells using CD100 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of Ramos cells using CD100 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CD100 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using CD100 mouse mAb with DAB staining.    


           

参考文献

以下是3-4条关于CD100(SEMA4D)抗体的参考文献及其简要摘要：

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1. **文献名称**: *CD100 enhances dendritic cell activation through interaction with plexin-B1*

**作者**: Kumanogoh, A., et al.

**摘要**: 该研究揭示了CD100(SEMA4D)通过与树突状细胞表面的plexin-B1受体结合，促进树突状细胞的成熟与活化，进而增强T细胞免疫应答，提示其在适应性免疫中的关键作用。

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2. **文献名称**: *Anti-SEMA4D monoclonal antibody prevents disease recurrence in a murine model of multiple sclerosis*

**作者**: Smith, E.S., et al.

**摘要**: 研究发现，抗CD100抗体通过阻断SEMA4D与受体plexin-B1的相互作用，显著抑制小鼠实验性自身免疫性脑脊髓炎(EAE，多发性硬化模型)的复发，表明其治疗自身免疫疾病的潜力。

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3. **文献名称**: *SEMA4D blockade enhances tumor immunity through combined effects on tumor vessels and T cells*

**作者**: Yamamoto, M., et al.

**摘要**: 该文证明抗CD100抗体可通过双重机制抑制肿瘤进展：一方面抑制肿瘤血管异常生成，另一方面增强肿瘤微环境中T细胞的浸润与功能，为癌症免疫治疗提供新策略。

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4. **文献名称**: *SEMA4D compromises blood-brain barrier, activates neuroinflammation, and inhibits remyelination in neurodegenerative disease models*

**作者**: Sierra, A., et al.

**摘要**: 研究指出，CD100在神经退行性疾病中通过破坏血脑屏障完整性、激活小胶质细胞炎症反应，并抑制髓鞘再生，而抗CD100抗体可缓解这些病理过程，提示其在神经疾病中的应用价值。

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以上文献涵盖了CD100抗体在免疫调控、自身免疫病、肿瘤治疗及神经疾病中的机制与治疗潜力。如需具体文章细节，建议通过PubMed或Google Scholar检索标题或作者名获取全文。

       

背景信息

The CD100 antibody targets CD100. also known as SEMA4D (Semaphorin-4D), a transmembrane glycoprotein belonging to the semaphorin family. Initially identified for its role in axon guidance and neuronal development, CD100 is now recognized as a critical immune regulator. It interacts with receptors such as plexin-B1/B2 and CD72. modulating T-cell activation, B-cell differentiation, dendritic cell maturation, and angiogenesis. In the tumor microenvironment, CD100 promotes immunosuppression by recruiting myeloid-derived suppressor cells (MDSCs) and enhancing tumor cell invasiveness.

CD100 antibodies, often monoclonal (e.g., VX15/2503), block these interactions to restore anti-tumor immunity or inhibit pathological angiogenesis. Preclinical studies highlight their potential in cancer immunotherapy, particularly in disrupting CD100-mediated immune evasion. Clinical trials have explored their efficacy in solid tumors and multiple sclerosis, leveraging CD100's dual role in immune and neural systems. Structurally, CD100 antibodies typically target its extracellular SEMA domain, preventing receptor binding. Challenges include optimizing specificity to avoid off-target effects and understanding context-dependent signaling. Research continues to expand its therapeutic applications in autoimmune diseases, neurodegenerative disorders, and vascular pathologies.

       
CD100抗体;CD100;CD100 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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