ADAP1抗体

The ADAP1 (ArfGAP with Dual PH Domains 1) antibody is a tool used to study the ADAP1 protein, a member of the ArfGAP (ADP-ribosylation factor GTPase-activating protein) family. ADAP1 regulates small GTPases of the Arf family, which are critical in membrane trafficking, cytoskeletal reorganization, and cellular signaling. Characterized by dual pleckstrin homology (PH) domains and a catalytic ArfGAP domain, ADAP1 interacts with phosphoinositides and facilitates GTP hydrolysis in Arf proteins, influencing vesicle transport and receptor trafficking. It is highly expressed in the brain, suggesting roles in neuronal development, synaptic plasticity, and neurodevelopmental disorders. Research links ADAP1 to cancer, immune regulation, and neurological conditions, with aberrant expression observed in tumors and neurodegenerative contexts. The ADAP1 antibody enables detection and localization of the protein via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into its molecular mechanisms and disease associations. Its applications span basic research and therapeutic target exploration.