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ALDOA抗体

Mouse Monoclonal ALDOA Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
ALDOA抗体
英文名称：
Mouse Monoclonal ALDOA Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 991 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
ALDOA

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesALDA; GSD12; HEL-S-87p
Entrez GeneID226
clone1C5B2
WB Predicted band size39.4kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenPurified recombinant fragment of human ALDOA (AA: 9-145) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using ALDOA mouse mAb against MCF-7 (1), Hela (2), and NIH/3T3 (3) cell lysate.    


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       Flow cytometric analysis of K562 cells using ALDOA mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using ALDOA mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human breast cancer tissues using ALDOA mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于ALDOA抗体的参考文献及其摘要概括：

1. **标题**：Autoantibodies against aldolase A in patients with systemic lupus erythematosus

**作者**：Meyer et al.

**摘要**：研究发现系统性红斑狼疮(SLE)患者血清中抗ALDOA自身抗体水平显著升高，提示ALDOA可能作为SLE的新型自身抗原，其抗体或与疾病活动性相关。

2. **标题**：Aldolase A as a biomarker for hepatocellular carcinoma

**作者**：Li et al.

**摘要**：通过免疫组化和Western blot分析，证实肝细胞癌(HCC)组织中ALDOA蛋白高表达，ALDOA抗体检测可作为HCC诊断及预后的潜在生物标志物。

3. **标题**：Anti-aldolase antibodies in autoimmune hepatitis

**作者**：Terrier et al.

**摘要**：在自身免疫性肝炎(AIH)患者中发现抗ALDOA抗体，提示其可能参与疾病发病机制，并与肝细胞损伤相关，为AIH诊断提供新血清学指标。

4. **标题**：ALDOA promotes lung cancer metastasis via glycolytic reprogramming

**作者**：Ji et al.

**摘要**：利用ALDOA抗体研究其在肺癌中的功能，发现ALDOA通过增强糖酵解促进肿瘤细胞侵袭转移，抗体阻断实验验证其作为治疗靶点的潜力。

       

背景信息

The ALDOA antibody targets aldolase A, a glycolytic enzyme encoded by the ALDOA gene. Aldolase A (ALDOA) is one of three aldolase isoforms (A, B, C) and plays a critical role in glycolysis by catalyzing the cleavage of fructose-1.6-bisphosphate into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. It is predominantly expressed in muscle tissues, erythrocytes, and other metabolically active cells, where it supports energy production. ALDOA also exhibits non-glycolytic functions, including interactions with cytoskeletal components like actin, suggesting roles in cell structure and motility.

ALDOA antibodies are widely used in research to study enzyme expression, localization, and dysfunction in diseases. Elevated ALDOA levels are associated with cancers, including hepatocellular carcinoma and lung adenocarcinoma, where it may promote tumor progression via enhanced glycolysis (Warburg effect) and metastasis-related pathways. Conversely, ALDOA deficiency is linked to rare inherited disorders like glycogen storage disease type XII (GSDXII), causing exercise intolerance and hemolytic anemia.

In diagnostics, ALDOA antibodies aid in detecting aldolase A in tissue samples, particularly in muscular pathologies. For example, increased serum aldolase (measured using specific antibodies) serves as a biomarker for muscle damage in inflammatory myopathies like dermatomyositis. Additionally, autoantibodies against ALDOA are occasionally observed in autoimmune conditions, highlighting its immunogenic potential. Commercial ALDOA antibodies are validated for techniques such as Western blotting, immunohistochemistry, and ELISA, contributing to both basic and clinical studies of metabolic and neuromuscular diseases.

       
ALDOA抗体;ALDOA;ALDOA Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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