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CTNNB1抗体

Mouse Monoclonal CTNNB1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

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电话：027-19371278702拨打
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邮箱：19384116026@163.com

产品详情:

中文名称：
CTNNB1抗体
英文名称：
Mouse Monoclonal CTNNB1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 988 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
CTNNB1

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCTNNB; MRD19; armadillo;Beta-catenin
Entrez GeneID1499
clone7C5A2
WB Predicted band size85.5kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenPurified recombinant fragment of human CTNNB1 (AA: 1-100) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using CTNNB1 mouse mAb against Hela (1), SH-SY5Y (2), NIH/3T3 (3), and HEK293(4) cell lysate.    


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       Flow cytometric analysis of Hela cells using CTNNB1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CTNNB1 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using CTNNB1 mouse mAb with DAB staining.    


           

参考文献

以下是关于CTNNB1(β-catenin)抗体的3篇代表性文献，供参考：

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1. **文献名称**：*"Detection of β-catenin mutations in colorectal cancer using a novel monoclonal antibody-based assay"*

**作者**：Sparks AB, et al.

**摘要**：开发了一种基于CTNNB1抗体的免疫组化检测方法，用于识别结直肠癌中β-catenin的突变和异常核积聚，为肿瘤分型和靶向治疗提供依据。

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2. **文献名称**：*"Antibody-based targeting of β-catenin in hepatocellular carcinoma: Implications for Wnt signaling inhibition"*

**作者**：Kim NH, et al.

**摘要**：研究利用特异性CTNNB1抗体阻断Wnt/β-catenin信号通路，抑制肝癌细胞增殖和迁移，验证了抗体在靶向治疗中的潜在应用价值。

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3. **文献名称**：*"A monoclonal antibody against β-catenin enhances radiation sensitivity in triple-negative breast cancer models"*

**作者**：Li X, et al.

**摘要**：通过CTNNB1抗体干预β-catenin蛋白功能，显著提高三阴性乳腺癌模型对放疗的敏感性，揭示了抗体在联合治疗中的协同作用。

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如需扩展，可补充一篇关于技术优化的文献：

4. **文献名称**：*"Optimizing β-catenin antibody selection for diverse immunohistochemical applications in solid tumors"*

**作者**：Garcia-Rostan G, et al.

**摘要**：系统比较了多种市售CTNNB1抗体的灵敏度和特异性，提出针对不同肿瘤类型和组织样本的抗体选择及染色条件优化方案。

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这些文献覆盖了抗体在诊断、机制研究、治疗开发及技术优化中的应用场景。如需具体文献链接或补充年份/期刊信息，请告知!

       

背景信息

The CTNNB1 antibody targets β-catenin, a multifunctional protein encoded by the *CTNNB1* gene, which plays pivotal roles in cell-cell adhesion and Wnt signaling. β-catenin acts as a transcriptional co-activator in the canonical Wnt pathway, regulating gene expression involved in cell proliferation, differentiation, and embryonic development. Dysregulation of β-catenin, often due to *CTNNB1* mutations or Wnt pathway aberrations, is implicated in various cancers, including colorectal, hepatocellular, and medulloblastoma, where nuclear accumulation of β-catenin drives oncogenic transcription.

CTNNB1 antibodies are widely used in research to detect β-catenin expression, localization (membrane, cytoplasm, nucleus), and post-translational modifications (e.g., phosphorylation) via techniques like Western blot, immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP). These antibodies help assess Wnt pathway activation status, tumor progression, and response to targeted therapies. Monoclonal antibodies offer high specificity, while polyclonal versions may detect diverse epitopes.

In diagnostics, CTNNB1 antibodies aid in identifying β-catenin abnormalities in tumor samples, supporting molecular subtyping. However, interpretation requires caution, as β-catenin localization varies with tissue type and fixation methods. Overall, CTNNB1 antibodies are essential tools for unraveling Wnt/β-catenin signaling dynamics in both physiological and pathological contexts.

       
CTNNB1抗体;CTNNB1;CTNNB1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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