GRM3抗体

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of SH-SY5Y cells using GRM3 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using GRM3 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using GRM3 mouse mAb with DAB staining.    

  
  

The GRM3 antibody targets the metabotropic glutamate receptor 3 (mGluR3), a class C G protein-coupled receptor encoded by the GRM3 gene. Expressed predominantly in the central nervous system, mGluR3 regulates glutamate signaling, influencing synaptic plasticity, neurotransmission, and neuronal development. It activates secondary messenger pathways via G proteins, modulating ion channel activity and intracellular calcium levels. GRM3 is implicated in neurological and psychiatric disorders, including schizophrenia, anxiety, autism spectrum disorders, and Alzheimer's disease, due to its role in glutamatergic dysfunction.

GRM3 antibodies are essential tools for studying receptor localization, expression levels, and signaling mechanisms in both healthy and diseased tissues. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate GRM3's involvement in synaptic regulation and disease pathology. Additionally, these antibodies aid in evaluating potential therapeutic agents targeting mGluR3. such as allosteric modulators. Research also explores GRM3's interaction with other neurotransmitter systems, including dopaminergic pathways, highlighting its broader impact on neural networks. As aberrant glutamate signaling is linked to cognitive deficits, GRM3 antibodies hold diagnostic and therapeutic relevance, particularly in drug development for neuropsychiatric conditions. Their specificity and reliability are critical for advancing mechanistic insights into GRM3-mediated processes and translational applications.