BAG1抗体

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of HeLa cells using BAG1 mouse mAb (green) and negative control (red).    

  
  

The BAG1 (Bcl-2-associated athanogene 1) antibody is a tool used to study the BAG1 protein, a critical regulator of cellular stress responses and apoptosis. BAG1 functions as a co-chaperone by binding to heat shock proteins (HSP70/HSC70), modulating their ability to fold client proteins or target them for degradation. It exists in multiple isoforms (e.g., p50. p46. p33) with distinct subcellular localizations (nuclear, cytoplasmic, or mitochondrial), influencing diverse pathways such as cell survival, proliferation, and hormone signaling.

BAG1 is implicated in cancer, where its overexpression in malignancies like breast cancer, leukemia, and prostate cancer correlates with poor prognosis and therapy resistance. Paradoxically, in certain contexts, it may act as a tumor suppressor by enhancing apoptosis. Beyond oncology, BAG1 interacts with tau protein in neurodegenerative diseases, potentially affecting Alzheimer’s pathology.

BAG1 antibodies are widely used in techniques (Western blot, IHC, immunofluorescence) to map protein expression, localization, and interactions. Their specificity for particular isoforms or phosphorylation states enables research into BAG1’s context-dependent roles. Studies leveraging these antibodies have advanced understanding of stress adaptation mechanisms, therapeutic targeting of chaperone systems, and disease biomarkers.