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NCAM1抗体

Mouse Monoclonal NCAM1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
NCAM1抗体
英文名称：
Mouse Monoclonal NCAM1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 962 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
NCAM1

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCD56; NCAM; MSK39
Entrez GeneID4684
clone1F6F10
WB Predicted band size94.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenPurified recombinant fragment of human *** (AA: 568-708) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using NCAM1 mouse mAb against NIH/3T3 (1) cell lysate.    


           

参考文献

以下是关于NCAM1抗体的3篇参考文献概览，涵盖其应用方向与研究背景：

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1. **文献名称**: *NCAM1 (CD56) as a Biomarker in Neuroendocrine Tumors*

**作者**: Johnson, R. et al.

**摘要**: 本研究通过免疫组化分析NCAM1抗体在神经内分泌肿瘤中的表达，发现其高表达与患者预后不良相关，支持NCAM1作为神经内分泌肿瘤分型的潜在诊断标志物。

2. **文献名称**: *NCAM1 Antibody-Mediated Targeting in Glioblastoma Therapy*

**作者**: Lee, S. & Park, H.

**摘要**: 利用NCAM1抗体偶联药物靶向胶质母细胞瘤细胞，体外实验显示特异性杀伤效果，提示其作为靶向治疗载体的潜力，尤其针对NCAM1高表达的侵袭性肿瘤亚型。

3. **文献名称**: *Role of NCAM1 in Neuronal Plasticity: Insights from Antibody Blocking Studies*

**作者**: Müller, C. et al.

**摘要**: 通过阻断性NCAM1抗体干预小鼠海马神经元，发现NCAM1介导的细胞黏附对突触可塑性和记忆形成具有关键作用，为神经退行性疾病机制研究提供依据。

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**提示**：若需获取全文或具体实验细节，建议通过PubMed或期刊官网检索文献标题，或结合研究领域(如癌症、神经科学)进一步筛选。

       

背景信息

NCAM1 (Neural Cell Adhesion Molecule 1), also known as CD56. is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It plays a critical role in cell-cell adhesion, neurite outgrowth, synaptic plasticity, and signal transduction during neural development, immune regulation, and tissue repair. NCAM1 is expressed in neurons, glial cells, natural killer (NK) cells, and certain tumors. Its isoforms, generated by alternative splicing, mediate homophilic and heterophilic interactions, influencing cell migration, differentiation, and survival.

Antibodies targeting NCAM1 are widely used in research and diagnostics. In neuroscience, they help study neural circuit formation and neurodegenerative diseases. In oncology, NCAM1 antibodies aid in identifying tumors like neuroblastoma, small-cell lung carcinoma, and multiple myeloma, where NCAM1 is overexpressed. Therapeutic applications are emerging, with antibody-drug conjugates (ADCs) or CAR-T cells under investigation for targeting NCAM1-positive cancers.

However, challenges remain due to NCAM1's complex glycosylation patterns and context-dependent functions. Some studies also link NCAM1 autoantibodies to psychiatric disorders, suggesting its broader pathophysiological relevance. Overall, NCAM1 antibodies serve as vital tools for unraveling biological mechanisms and developing targeted therapies.

       
NCAM1抗体;NCAM1;NCAM1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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