基本信息 产品详情 公司简介 推荐产品
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
网站主页 化工产品目录 生物化工 抗体 SMARCA1 antibody SMARCA1抗体
  • SMARCA1抗体
  • SMARCA1抗体
  • SMARCA1抗体

1/3

SMARCA1抗体

Mouse Monoclonal SMARCA1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
SMARCA1抗体
英文名称：
Mouse Monoclonal SMARCA1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 953 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
SMARCA1

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesSWI; ISWI; SWI2; SNF2L; SNF2L1; SNF2LB; SNF2LT; hSNF2L; NURF140
Entrez GeneID6594
clone2H7B8
WB Predicted band size122.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
ImmunogenPurified recombinant fragment of human SMARCA1 (AA: 933-1070) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

  •  

     

       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


  •  

     

       Western blot analysis using SMARCA1 mouse mAb against SW620 (1) and HT-29 (2) cell lysate.    


  •  

     

       Flow cytometric analysis of NIH/3T3 cells using SMARCA1 mouse mAb (green) and negative control (red).    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using SMARCA1 mouse mAb with DAB staining.    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using SMARCA1 mouse mAb with DAB staining.    


           

参考文献

以下是关于SMARCA1抗体的3篇代表性文献摘要(基于公开研究领域知识，非真实文献)：

---

1. **文献名称**: "SMARCA1 regulates pluripotency and chromatin remodeling in embryonic stem cells"

**作者**: Li, Y. et al.

**摘要**: 本研究利用特异性SMARCA1抗体，通过ChIP-seq和免疫共沉淀技术，揭示了SMARCA1在小鼠胚胎干细胞中维持多能性和染色质动态重塑中的关键作用。实验表明，SMARCA1缺失导致分化相关基因异常激活。

2. **文献名称**: "Development and validation of a monoclonal antibody for SMARCA1 in human tissues"

**作者**: Garcia, S. & Patel, R.

**摘要**: 报道了一种高特异性人源SMARCA1单克隆抗体的开发与验证。通过Western blot、免疫组化和流式细胞术证实了抗体在多种组织中的可靠性，并发现SMARCA1在肺癌组织中表达显著下调。

3. **文献名称**: "Functional interplay between SMARCA1 and SMARCA4 in chromatin remodeling complexes"

**作者**: Wang, X. et al.

**摘要**: 本研究通过SMARCA1抗体敲低实验，结合蛋白质互作分析，揭示了SMARCA1与SMARCA4(BRG1)在SWI/SNF复合体中的协同调控机制，阐明了二者在DNA损伤修复通路中的不同功能贡献。

---

注：以上文献为示例性内容，实际研究中建议通过PubMed或Google Scholar以“SMARCA1 antibody”为关键词检索真实文献。

       

背景信息

The SMARCA1 antibody is a crucial tool for studying the SMARCA1 protein, a key component of the SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling complex. SMARCA1. also known as SNF2L, is an ATP-dependent chromatin remodeler that regulates gene expression by altering nucleosome positioning, facilitating transcriptional activation or repression. It shares homology with the yeast ISWI (Imitation Switch) protein and plays roles in diverse cellular processes, including differentiation, DNA repair, and replication.

Antibodies targeting SMARCA1 are widely used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to investigate its expression, localization, and interaction partners. These antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions of the protein, and validated for specificity using knockout controls or siRNA-mediated depletion.

Research utilizing SMARCA1 antibodies has revealed its involvement in neurodevelopment, stem cell maintenance, and cancer. Dysregulation of SMARCA1 is linked to intellectual disabilities and malignancies, underscoring its importance in both normal physiology and disease. Commercial SMARCA1 antibodies are available from multiple suppliers, with host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal) varying depending on experimental requirements. Proper validation remains critical to ensure reliable detection, given potential cross-reactivity with homologous SWI/SNF subunits like SMARCA2 (SNF2H).

       
SMARCA1抗体;SMARCA1;SMARCA1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

SMARCA1抗体相关厂家报价

  • 抗CRF抗体
  • 抗CRF抗体
  • 维百奥（北京）生物科技有限公司 VIP
  • 2025-12-29
  • 询价
内容声明
official 进入官方账号
拨打电话 立即询价