RIPK4抗体

The RIPK4 (Receptor-interacting protein kinase 4) antibody is a crucial tool for studying the role of RIPK4. a serine/threonine kinase belonging to the RIP kinase family. RIPK4 is involved in cellular processes such as apoptosis, inflammation, and epidermal differentiation, primarily through its interaction with signaling pathways like PKCδ and NF-κB. Mutations in the RIPK4 gene are linked to developmental disorders, including Bartsocas-Papas syndrome, characterized by severe skin and limb abnormalities. Researchers use RIPK4 antibodies to detect protein expression, localization, and post-translational modifications in various experimental models, such as Western blotting, immunofluorescence, and immunohistochemistry. These antibodies aid in exploring RIPK4's role in cancer (e.g., squamous cell carcinoma), skin development, and immune regulation. Commercial RIPK4 antibodies are typically monoclonal or polyclonal, validated for specificity using knockout/knockdown controls. Their application extends to both basic research and clinical studies, particularly in understanding molecular mechanisms of epithelial morphogenesis, tumorigenesis, and inflammatory diseases. Reliable RIPK4 antibodies are essential for elucidating its dual roles in pro-survival and pro-apoptotic signaling, depending on cellular context and stress conditions.