ANAPC1抗体

The ANAPC1 antibody targets the Anaphase-Promoting Complex/Cyclosome subunit 1 (ANAPC1), a critical component of the APC/C, a multi-subunit E3 ubiquitin ligase essential for cell cycle regulation. The APC/C governs the transition from metaphase to anaphase and exit from mitosis by ubiquitinating key cell cycle regulators, such as cyclins and securins, marking them for proteasomal degradation. ANAPC1 serves as a scaffolding protein that stabilizes the APC/C structure and facilitates substrate recognition. Dysregulation of APC/C function, including ANAPC1. is implicated in genomic instability, mitotic errors, and diseases like cancer. ANAPC1 antibodies are widely used in research to study its expression, localization, and interactions in cell cycle control mechanisms. They aid in detecting ANAPC1 via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Studies using these antibodies have revealed associations between ANAPC1 mutations or altered expression and tumorigenesis, chemotherapy resistance, and developmental disorders. Additionally, ANAPC1 antibodies contribute to exploring APC/C's role in non-mitotic processes, such as neuronal differentiation and metabolism. Their specificity and validation across experimental models make them vital tools for dissecting APC/C-mediated regulatory networks in health and disease.