SAG2抗体

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Western blot analysis using SAG2 mouse mAb against SW480 (1), A431 (2), and K562 (3) cell lysate.    

  
  

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     Flow cytometric analysis of Hela cells using SAG2 mouse mAb (green) and negative control (red).    

  
  

**Background of SAG2 Antibody**

SAG2 (Surface Antigen 2) is a key protein associated with *Toxoplasma gondii*, an obligate intracellular parasite responsible for toxoplasmosis. As a member of the SAG1-related gene family (SRS), SAG2 is predominantly expressed on the surface of the parasite’s tachyzoite stage, playing a critical role in host cell adhesion, immune evasion, and invasion. Its immunodominant nature makes it a major target for diagnostic and research applications.

Antibodies against SAG2 are widely used in serological assays to detect *T. gondii* infection. IgG and IgM antibodies specific to SAG2 help distinguish acute from chronic infections, aiding clinical management, particularly in pregnant women and immunocompromised individuals. Recombinant SAG2 or synthetic peptides are often employed in ELISA or immunoblotting to ensure high specificity and sensitivity.

Research on SAG2 antibodies also contributes to vaccine development, as SAG2 is a candidate antigen for inducing protective immunity. Monoclonal antibodies against SAG2 are valuable tools for studying parasite biology, including host-pathogen interactions and stage-specific antigen expression. However, genetic diversity in SAG2 across *T. gondii* strains may influence antibody binding efficiency, necessitating careful validation in diagnostic and research settings.

Overall, SAG2 antibodies are indispensable in understanding toxoplasmosis pathogenesis, improving diagnostics, and advancing therapeutic strategies against this globally prevalent infection.