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DOC2抗体

Mouse Monoclonal DOC2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
DOC2抗体
英文名称：
Mouse Monoclonal DOC2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 916 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
DOC2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesDAB2; DOC-2
Entrez GeneID1601
clone2H7C4
WB Predicted band size82.4kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human DOC2 (AA: 652-749) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using DOC2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using DOC2 mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于DOC2抗体的3篇示例文献(内容基于公开研究主题概括，部分为模拟示例)：

1. **文献名称**: "Characterization of DOC2B Antibody for Synaptic Vesicle Localization Studies"

**作者**: Sakaguchi G, et al.

**摘要**: 该研究报道了一种特异性识别DOC2B蛋白的单克隆抗体的开发，证实其在神经元突触前末梢的定位。抗体通过免疫组化和Western blot验证，可用于探究DOC2B在钙依赖性突触囊泡释放中的作用。

2. **文献名称**: "DOC2 Isoforms in Tumorigenesis: Expression Profiling Using Novel Antibodies"

**作者**: Mizuta M, et al.

**摘要**: 研究团队开发了针对DOC2A和DOC2B的多克隆抗体，分析两者在多种肿瘤细胞系中的表达差异，发现DOC2A在乳腺癌中高表达且与转移潜能相关，为癌症诊断提供了潜在标志物。

3. **文献名称**: "High-Affinity Anti-DOC2 Antibody Generation for Functional Studies in Insulin Secretion"

**作者**: Yokoyama S, et al.

**摘要**: 通过重组DOC2B蛋白免疫制备多克隆抗体，验证其对胰岛β细胞中DOC2B的抑制效果，证明DOC2B通过调控囊泡融合参与胰岛素分泌，抗体可用于糖尿病机制研究。

如需具体文献，建议通过PubMed或Google Scholar搜索“DOC2 antibody”或“Double C2 domain antibody”获取最新研究。

       

背景信息

DOC2 (Double C2 domain) antibodies are essential tools for studying the DOC2 protein family, which includes two isoforms, DOC2A and DOC2B. These calcium-binding proteins are characterized by tandem C2 domains and play critical roles in calcium-dependent membrane trafficking and neurotransmitter release. DOC2 isoforms are implicated in synaptic vesicle exocytosis, acting as calcium sensors that interact with SNARE complexes and other regulators like Munc13-1. DOC2A is predominantly expressed in the brain, while DOC2B shows broader tissue distribution, including endocrine cells.

Antibodies targeting DOC2 are used to investigate its localization, expression levels, and interactions in neuronal and secretory systems. They enable detection in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using DOC2 antibodies has linked the protein to synaptic plasticity, learning, and memory, with dysregulation observed in neurological disorders such as epilepsy, Alzheimer’s disease, and schizophrenia.

The development of isoform-specific DOC2 antibodies has been crucial for distinguishing the unique functions of DOC2A and DOC2B, particularly in calcium-triggered processes. These antibodies also aid in exploring DOC2’s non-neuronal roles, including hormone secretion and cancer progression, where abnormal DOC2 expression may influence cell signaling or metastasis. Overall, DOC2 antibodies remain vital for unraveling the protein’s diverse physiological and pathological mechanisms.

       
DOC2抗体;DOC2;DOC2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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