SYK抗体

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Immunofluorescence analysis of Hela cells using SYK mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    

  
  

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     Flow cytometric analysis of Hela cells using SYK mouse mAb (green) and negative control (red).    

  
  

Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase critical for immune signaling, particularly in pathways activated by B-cell receptors (BCR) and certain Fc receptors. It plays a central role in regulating immune cell activation, proliferation, and survival. Structurally, SYK contains tandem SH2 domains that bind phosphorylated immunoreceptor tyrosine-based activation motifs (ITAMs), triggering downstream signaling cascades. Dysregulated SYK activity is implicated in autoimmune diseases (e.g., rheumatoid arthritis), hematologic malignancies (e.g., B-cell lymphomas), and inflammatory conditions, making it a therapeutic target.

SYK-specific antibodies are essential tools for studying its expression, phosphorylation status, and interactions in both physiological and pathological contexts. They enable detection of SYK in tissues/cells via techniques like Western blot, immunohistochemistry, and flow cytometry. Therapeutic anti-SYK antibodies are being explored to modulate immune responses or block oncogenic signaling. Small-molecule SYK inhibitors have shown clinical potential, but antibodies offer advantages in specificity for targeting extracellular epitopes or protein-protein interfaces. Research continues to clarify SYK's dual roles in immune regulation and disease pathogenesis, driving antibody-based diagnostic and therapeutic innovations.