基本信息 产品详情 公司简介 推荐产品
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
网站主页 化工产品目录 生物化工 抗体 SOD2 抗体 SOD2抗体
  • SOD2抗体
  • SOD2抗体
  • SOD2抗体

1/3

SOD2抗体

Mouse Monoclonal SOD2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
SOD2抗体
英文名称：
Mouse Monoclonal SOD2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 900 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
SOD2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/50 - 1/250 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesIPOB; IPO-B; MNSOD; MVCD6; Mn-SOD
Entrez GeneID6648
clone8H3D2
WB Predicted band size24.7kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human SOD2 (AA: 1-222) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

  •  

     

       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


  •  

     

       Immunofluorescence analysis of Hela cells using SOD2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


  •  

     

       Flow cytometric analysis of Hela cells using SOD2 mouse mAb (green) and negative control (red).    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using SOD2 mouse mAb with DAB staining.    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using SOD2 mouse mAb with DAB staining.    


           

参考文献

以下是3-4条关于SOD2抗体的参考文献及其简要摘要：

---

1. **文献名称**：*"Age-related loss of mitochondrial SOD2 impairs redox homeostasis and promotes cellular senescence"*

**作者**：Holly Van Remmen 等

**摘要**：研究利用SOD2抗体检测小鼠衰老模型中SOD2蛋白表达，发现年龄相关的SOD2下调导致线粒体氧化应激加剧，加速细胞衰老，提示SOD2在维持氧化还原稳态中的关键作用。

---

2. **文献名称**：*"SOD2 deficiency promotes amyloid-beta aggregation in Alzheimer's disease models"*

**作者**：Daret St. Clair 等

**摘要**：通过SOD2抗体分析阿尔茨海默病小鼠脑组织，发现SOD2表达减少与线粒体超氧化物积累相关，促进Aβ斑块形成，表明SOD2缺失可能加剧神经退行性病变。

---

3. **文献名称**：*"SOD2-mediated antioxidant defense regulates cancer stem cell plasticity in glioblastoma"*

**作者**：Peng Huang 等

**摘要**：使用SOD2抗体研究胶质母细胞瘤细胞，发现SOD2通过调控活性氧(ROS)水平影响肿瘤干细胞的自我更新和化疗耐药性，提示靶向SOD2可能增强抗癌疗效。

---

4. **文献名称**：*"Post-translational modification of SOD2 modulates its enzymatic activity in cardiovascular disease"*

**作者**：Tohru Fukai 等

**摘要**：通过SOD2抗体结合质谱分析，揭示SOD2的乙酰化修饰在心血管疾病中影响其酶活性和抗氧化功能，为治疗氧化应激相关疾病提供新靶点。

---

这些文献覆盖了SOD2在衰老、神经疾病、癌症及心血管疾病中的功能研究，均通过SOD2抗体进行蛋白表达或定位分析，体现了其在基础与临床研究中的广泛应用。

       

背景信息

Superoxide dismutase 2 (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is a mitochondrial antioxidant enzyme that catalyzes the conversion of superoxide radicals into hydrogen peroxide and oxygen, protecting cells from oxidative damage. SOD2 plays a critical role in maintaining redox balance and mitochondrial function, with implications in aging, inflammation, and various diseases. Antibodies targeting SOD2 are essential tools for detecting its expression, localization, and regulation in biological systems.

SOD2 antibodies are widely used in research to study oxidative stress-related pathologies, including cancer, neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s), cardiovascular diseases, and diabetes. They enable techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to quantify SOD2 levels in tissues or cultured cells. These antibodies help elucidate SOD2's dual role in cancer—acting as a tumor suppressor in early stages but potentially promoting metastasis in advanced malignancies.

Commercial SOD2 antibodies are typically raised against specific epitopes of human or murine SOD2. with validations across species and applications. Researchers prioritize antibodies with high specificity, minimal cross-reactivity (e.g., with SOD1 or SOD3), and compatibility with formalin-fixed or frozen samples. Recent studies also explore SOD2's involvement in metabolic reprogramming and immune modulation, expanding its relevance in therapeutic targeting. Understanding SOD2 dynamics through antibody-based assays remains pivotal for advancing antioxidant therapies and precision medicine.

       
SOD2抗体;SOD2;SOD2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

SOD2抗体相关厂家报价

内容声明
official 进入官方账号
拨打电话 立即询价