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C3C抗体

Mouse Monoclonal C3C Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期:2025-05-10

湖北瑞和宁生物科技有限公司

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电话:027-19371278702拨打
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邮箱:19384116026@163.com

产品详情:

中文名称:
C3C抗体
英文名称:
Mouse Monoclonal C3C Antibody
品牌:
艾普蒂
产地:
武汉
保存条件:
Stored at -20°C for 878 year. Avoid repeated freeze / thaw cycles.
产品类别:
抗体
重组:
应用:
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性:
Human,Mouse,Rat
宿主:
Mouse
偶联物:
靶点:
C3C

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p
Entrez GeneID718
clone8B5H2
WB Predicted band size187.1kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human C3C (AA: 1521-1649) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using C3C mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using C3C mouse mAb with DAB staining.    


           

参考文献

以下是关于C3c抗体的3篇参考文献及简要摘要:

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1. **文献名称**: *"C3c is a marker for complement activation in IgA nephropathy"*

**作者**: Zhang, H., et al.

**摘要**: 该研究探讨了IgA肾病中补体激活的机制,发现肾组织中的C3c沉积可作为补体替代途径激活的标志物。通过免疫组化分析,C3c抗体检测显示其沉积水平与疾病严重程度相关,提示其在评估肾损伤中的潜在临床价值。

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2. **文献名称**: *"Autoantibodies against complement C3c in systemic lupus erythematosus"*

**作者**: Trendelenburg, M., et al.

**摘要**: 研究报道了系统性红斑狼疮(SLE)患者中存在抗C3c自身抗体,这些抗体通过结合补体C3c片段干扰补体调控功能,可能导致免疫复合物清除障碍和炎症加剧,揭示了其在SLE发病机制中的潜在作用。

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3. **文献名称**: *"C3c immunohistochemistry improves the histological assessment of renal biopsies"*

**作者**: Sato, Y., et al.

**摘要**: 该文献提出使用C3c抗体进行肾活检组织的免疫组化分析,能够更敏感地检测补体激活状态。研究表明,C3c沉积模式有助于区分不同肾小球疾病的病理类型,为临床诊断和治疗提供参考。

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**注**:以上文献信息为示例性内容,实际文献需通过学术数据库(如PubMed、Web of Science)检索确认。若需具体文献,建议结合关键词“C3c antibody”、“complement C3c”进一步查询。

       

背景信息

C3c antibodies are immunological tools targeting the C3c fragment of complement component 3 (C3), a central protein in the complement system. The complement system, a key part of innate immunity, enhances pathogen clearance, inflammation, and tissue homeostasis. C3 is cleaved during complement activation into C3a (anaphylatoxin) and C3b (opsonin). Further degradation of C3b generates C3c and C3dg. C3c, a stable degradation product, retains antigenic epitopes useful for detecting complement activation.

C3c antibodies are widely used in research and diagnostics to identify complement activation in diseases. In clinical settings, they help detect C3c deposits in tissues (e.g., renal biopsies in glomerulonephritis) or measure circulating C3c levels as a biomarker for systemic complement activation in autoimmune disorders, infections, or inflammatory conditions. Their specificity for C3c ensures differentiation from intact C3 or other cleavage fragments, providing insights into disease mechanisms and therapeutic monitoring.

These antibodies are essential in immunoassays (e.g., ELISA, immunohistochemistry) and flow cytometry, aiding both basic research and diagnostic workflows. Their role in identifying complement-driven pathology underscores their importance in understanding immune dysregulation and guiding targeted therapies.

       
C3C抗体;C3C;C3C Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ¥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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