PTPN14抗体

The PTPN14 antibody is a tool used to study the protein tyrosine phosphatase, non-receptor type 14 (PTPN14), a member of the non-receptor protein tyrosine phosphatase (PTP) family. PTPN14 regulates cellular signaling by dephosphoryrating tyrosine residues on target proteins, influencing processes like cell adhesion, migration, and proliferation. It interacts with key signaling pathways, including the Hippo-YAP pathway, where it acts as a tumor suppressor by inhibiting oncogenic YAP/TAZ activity. PTPN14 is also implicated in developmental processes, such as vascular and lymphatic formation, through its role in modulating VE-cadherin and other adhesion molecules. Dysregulation of PTPN14 is linked to cancers (e.g., breast, colorectal) and developmental disorders. Researchers use PTPN14 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression, localization, and functional mechanisms. Specificity and validation of these antibodies are critical due to potential cross-reactivity with other PTPs. Studies on PTPN14 aim to uncover therapeutic targets, particularly in cancers with Hippo pathway alterations.