POMC抗体

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     OR5AS1 Antibody (C-term) (Cat. #P31043) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the OR5AS1 antibody detected the OR5AS1 protein (arrow).    

  
  

The pro-opiomelanocortin (POMC) antibody is a critical tool in biomedical research and diagnostics, targeting the POMC precursor protein. POMC is a polypeptide hormone precursor expressed primarily in the hypothalamus, pituitary gland, and skin. It undergoes tissue-specific proteolytic cleavage to yield biologically active peptides, including adrenocorticotropic hormone (ACTH), β-endorphin, and α-melanocyte-stimulating hormone (α-MSH). These peptides regulate diverse physiological processes, such as stress response, energy homeostasis, pain modulation, and pigmentation.

POMC antibodies are widely used to detect and quantify POMC-derived peptides in experimental and clinical settings. In research, they facilitate studies on endocrine signaling, metabolic disorders (e.g., obesity), and adrenal dysfunction. Clinically, they aid in diagnosing conditions like Cushing’s syndrome (linked to ACTH overproduction) and neuroendocrine tumors. Antibodies targeting specific regions of POMC (e.g., ACTH or β-endorphin epitopes) enable precise detection in immunoassays, immunohistochemistry, or Western blotting.

The development of high-specificity POMC antibodies is challenging due to the protein’s post-translational processing and homology across species. Validation for cross-reactivity and sensitivity is crucial, particularly in distinguishing intact POMC from its fragments. Recent advancements in monoclonal antibody technology have improved reproducibility, supporting both mechanistic studies and therapeutic exploration, such as targeting POMC pathways for obesity treatment.