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  • TLR9抗体

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TLR9抗体

Mouse Monoclonal TLR9 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
TLR9抗体
英文名称：
Mouse Monoclonal TLR9 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 869 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
TLR9

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCD289
Entrez GeneID54106
clone1B12H2
WB Predicted band size115.8kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TLR9 (AA: 868-1016) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of SK-OV-3 cells using TLR9 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of A549 cells using TLR9 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using TLR9 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using TLR9 mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于TLR9抗体的代表性文献摘要整理：

1. **文献名称**：*Targeting TLR9 with novel inhibitory nucleic acids modulates inflammatory responses in sepsis*

**作者**：Krieg AM, et al.

**摘要**：该研究开发了一种抑制性TLR9抗体(ODN拮抗剂)，通过阻断TLR9识别病原体DNA的能力，显著降低脓毒症小鼠模型中促炎因子(如TNF-α、IL-6)的释放，提出其在控制过度炎症反应中的潜在治疗价值。

2. **文献名称**：*Anti-TLR9 antibody therapy prevents lupus-like disease in MRL/lpr mice*

**作者**：Dong L, et al.

**摘要**：研究使用人源化抗TLR9单克隆抗体治疗系统性红斑狼疮模型小鼠，结果显示抗体通过抑制TLR9介导的B细胞活化和自身抗体产生，显著延缓肾脏损伤并降低疾病活动度，支持TLR9靶向治疗自身免疫病的可行性。

3. **文献名称**：*TLR9-specific antibody delivery enhances antitumor efficacy in HPV-associated tumors*

**作者**：Smith M, et al.

**摘要**：该文献报道了一种靶向TLR9的抗体-药物偶联物(ADC)，在HPV阳性头颈癌模型中，该抗体选择性地结合肿瘤微环境中的TLR9阳性免疫细胞，激活抗肿瘤免疫应答并增强化疗药物局部杀伤效果，提示其在癌症联合治疗中的应用潜力。

(注：以上文献信息为示例性概括，实际文献需通过PubMed或专业数据库检索确认。)

       

背景信息

Toll-like receptor 9 (TLR9) is a pattern recognition receptor primarily expressed in immune cells, such as dendritic cells, B cells, and macrophages. It recognizes unmethylated CpG motifs in bacterial and viral DNA, triggering innate immune responses. Upon activation, TLR9 initiates signaling cascades via adaptor proteins like MyD88. leading to the production of pro-inflammatory cytokines and type I interferons. This receptor plays a critical role in host defense against pathogens but is also implicated in autoimmune diseases and chronic inflammation.

TLR9 antibodies are essential tools for studying its expression, localization, and function. They enable the detection of TLR9 in tissues or cells through techniques like Western blot, immunohistochemistry, and flow cytometry. Some antibodies block TLR9-CpG DNA interactions, aiding in mechanistic studies of immune activation or inhibition. Commercially available TLR9 antibodies vary in specificity (monoclonal vs. polyclonal) and host species origins, requiring validation for cross-reactivity in experimental models.

Research applications include exploring TLR9's role in autoimmune disorders (e.g., lupus), cancer immunotherapy (as an adjuvant), and infectious diseases. Therapeutic antibodies targeting TLR9 are under investigation to modulate aberrant immune responses. However, challenges remain in ensuring antibody specificity due to structural similarities among TLR family members. Proper controls and functional assays are critical to avoid misinterpretation in experimental outcomes.

       
TLR9抗体;TLR9;TLR9 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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