DAPP1抗体

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of A549 cells using DAPP1 mouse mAb (green) and negative control (red).    

  
  

DAPP1 (dual adaptor of phosphotyrosine and 3-phosphoinositides), also known as Bam32. is a signaling adaptor protein involved in regulating immune cell activation, particularly in B lymphocytes. It contains an N-terminal SH2 domain that binds phosphotyrosine residues and a C-terminal PH domain that interacts with phosphatidylinositol (3.4.5)-trisphosphate (PIP3), linking receptor-activated tyrosine kinases to downstream pathways. DAPP1 plays a role in B-cell receptor (BCR) signaling, influencing cell survival, proliferation, and differentiation by modulating Akt, MAPK, and NF-κB pathways. Its expression is predominantly observed in lymphoid tissues.

DAPP1 antibodies are immunological tools designed to detect and study the expression, localization, and function of this protein. They are widely used in research to investigate B-cell development, immune dysregulation, and malignancies like B-cell lymphomas. Polyclonal and monoclonal anti-DAPP1 antibodies are generated using immunogenic peptide sequences from conserved regions of the protein. Validation typically includes Western blotting, immunohistochemistry, and flow cytometry. Dysregulation of DAPP1 has been implicated in autoimmune diseases and cancers, making its study critical for understanding immune signaling networks and therapeutic targeting. These antibodies aid in elucidating mechanisms of immune cell activation and pathological conditions linked to DAPP1 dysfunction.