Tlr2抗体

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Western blot analysis using Tlr2 mouse mAb against Ramos (1), U937 (2), Jurkat (3), and Hela (4) cell lysate.    

  
  

**Background of TLR2 Antibodies**

Toll-like receptor 2 (TLR2) is a key pattern recognition receptor in the innate immune system, responsible for detecting conserved microbial components such as bacterial lipoproteins, peptidoglycan, and lipoteichoic acid. It plays a critical role in initiating immune responses by activating signaling pathways (e.g., NF-κB, MAPK) that drive inflammation and host defense. TLR2 forms heterodimers with TLR1 or TLR6. enabling recognition of diverse pathogens.

TLR2 antibodies are essential tools for studying TLR2 expression, localization, and function in immune cells and tissues. They are widely used in techniques like flow cytometry, Western blotting, immunohistochemistry, and ELISA to quantify TLR2 levels or block its activity in experimental models. Researchers employ these antibodies to investigate TLR2's role in infectious diseases, autoimmune disorders (e.g., rheumatoid arthritis), atherosclerosis, and neurodegenerative conditions.

Monoclonal TLR2 antibodies offer high specificity, while polyclonal variants may detect broader epitopes. Challenges include ensuring cross-reactivity across species (human, mouse, rat) and distinguishing functional from non-functional receptor forms. Recent studies also explore therapeutic applications, such as modulating TLR2 signaling in sepsis or chronic inflammation. Overall, TLR2 antibodies remain pivotal in dissecting immune mechanisms and developing targeted therapies.