OTUD4抗体

+ +

•  

   

     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

•  

   

     Western blot analysis using OTUD4 mouse mAb against HepG2 (1) and C6 (2) cell lysate.    

  
  

•  

   

     Flow cytometric analysis of Hela cells using OTUD4 mouse mAb (green) and negative control (red).    

  
  

The OTUD4 antibody is a crucial tool for studying the OTUD4 protein, a deubiquitinating enzyme belonging to the ovarian tumor (OTU) domain-containing protease family. OTUD4. also known as DUBA4 or OTU domain-containing protein 4. regulates cellular processes by removing ubiquitin chains from substrate proteins, thereby modulating protein stability, localization, and activity. It plays roles in DNA damage repair, immune response regulation, and apoptosis. Research highlights its involvement in the NF-κB signaling pathway and interactions with proteins like p53. suggesting links to cancer and autoimmune disorders.

OTUD4 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect OTUD4 expression, quantify protein levels, and investigate its molecular interactions. These antibodies are typically validated for specificity and sensitivity across human and model organism samples. Recent studies explore OTUD4's potential as a therapeutic target, particularly in diseases marked by dysregulated ubiquitination, such as certain cancers or neurodegenerative conditions. Its dual role in promoting or suppressing tumorigenesis, depending on cellular context, underscores the need for reliable research tools like OTUD4 antibodies to dissect its complex functions. Commercial OTUD4 antibodies are available as monoclonal or polyclonal variants, often with species-specific reactivity. Proper validation via knockout controls or siRNA knockdown remains essential to ensure experimental accuracy.