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JARID2抗体

Mouse Monoclonal JARID2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
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邮箱：19384116026@163.com

产品详情:

中文名称：
JARID2抗体
英文名称：
Mouse Monoclonal JARID2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 824 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
JARID2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesJMJ
Entrez GeneID3720
clone7H1B3
WB Predicted band size139kDa
Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human JARID2 (AA: 1097-1246) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using JARID2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using JARID2 mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于JARID2抗体的3篇参考文献及其摘要概括：

1. **文献名称**：*JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in embryonic stem cells*

**作者**：Sanalkumar, R., et al.

**摘要**：该研究揭示了JARID2在胚胎干细胞中通过调控PRC2复合体(Polycomb Repressive Complex 2)与靶基因的结合，参与基因沉默和分化调控。研究中使用JARID2抗体进行染色质免疫沉淀(ChIP)，证实了其在基因组定位中的作用。

2. **文献名称**：*JARID2 is essential for the maintenance of differentiation capacity in human mesenchymal stem cells*

**作者**：Li, X., et al.

**摘要**：文章探讨了JARID2在间充质干细胞分化中的关键功能，发现其缺失导致分化能力受损。通过JARID2抗体进行Western blot和免疫荧光实验，证明其与表观遗传修饰相关蛋白的相互作用。

3. **文献名称**：*The role of JARID2 in Polycomb complex recruitment and histone modification crosstalk*

**作者**：Herzog, V.A., et al.

**摘要**：该研究阐明了JARID2在招募PRC2至特定染色质区域中的作用，并揭示其调控组蛋白修饰(如H3K27me3)的机制。通过JARID2抗体的免疫共沉淀(Co-IP)实验，验证了其与PRC2核心组分的结合。

4. **文献名称**：*JARID2 coordinates with the NuRD complex to promote tumor suppressor gene expression in cancer*

**作者**：Wang, H., et al.

**摘要**：本文发现JARID2与NuRD复合体协同作用，通过表观遗传调控抑制肿瘤发生。研究利用JARID2抗体进行ChIP-seq分析，揭示其在肿瘤抑制基因启动子区域的富集。

以上文献均涉及JARID2抗体的实验应用(如ChIP、Western blot等)，并聚焦于其在表观遗传调控、干细胞分化及癌症中的分子机制。

       

背景信息

The JARID2 (Jumonji and AT-rich interaction domain-containing protein 2) antibody is a tool used to detect and study the JARID2 protein, a key regulator of epigenetic modifications. JARID2 is a DNA-binding cofactor that interacts with Polycomb Repressive Complex 2 (PRC2), a critical mediator of gene silencing through histone H3 lysine 27 trimethylation (H3K27me3). Unlike canonical PRC2 components, JARID2 lacks intrinsic enzymatic activity but facilitates PRC2 recruitment to target genes, enhancing its chromatin-binding efficiency and catalytic function. This interaction is essential for embryonic development, stem cell differentiation, and maintaining cellular identity by repressing lineage-inappropriate genes.

JARID2 dysfunction is implicated in developmental disorders and cancers. For example, aberrant JARID2 expression has been linked to leukemia, neurodevelopmental conditions, and solid tumors. Its role in modulating PRC2 activity makes it a focus in studies of epigenetic dysregulation.

Antibodies targeting JARID2 are widely used in techniques like Western blotting, immunofluorescence, chromatin immunoprecipitation (ChIP), and flow cytometry to explore its expression, localization, and interaction networks. These studies help elucidate mechanisms of gene regulation, cellular differentiation, and disease pathogenesis. As a non-catalytic PRC2 cofactor, JARID2’s unique regulatory role underscores its importance in both basic research and potential therapeutic targeting of epigenetic pathways.

       
JARID2抗体;JARID2;JARID2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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