SH3GL1抗体

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Hela cells using SH3GL1 mouse mAb (green) and negative control (red).    

  
  

SH3GL1 (SH3 domain-containing GRB2-like 1), also known as EEN-B1 or CNSA1. is a member of the Bin-Amphiphysin-Rvs (BAR) domain protein family. It plays a role in membrane trafficking, endocytosis, and synaptic vesicle recycling by facilitating membrane curvature and vesicle formation. The SH3GL1 antibody is a crucial tool for studying its expression, localization, and function in cellular processes. This antibody specifically recognizes the SH3GL1 protein, which contains an N-terminal BAR domain for membrane binding and a C-terminal SH3 domain that interacts with proline-rich motifs in partner proteins like endophilins and dynamin.

Research using SH3GL1 antibodies has linked the protein to clathrin-mediated endocytosis, receptor tyrosine kinase signaling (e.g., EGFR degradation), and neuronal communication. Its involvement in membrane dynamics makes it relevant to cancer research, particularly in tumorigenesis and metastasis, where altered endocytic trafficking may influence cell signaling. In neuroscience, SH3GL1 antibodies help investigate synaptic vesicle recycling defects associated with neurodegenerative diseases.

Commercially available SH3GL1 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression levels or subcellular distribution. Validation typically includes testing in knockout cell lines or tissues to ensure specificity. Studies employing these antibodies continue to reveal SH3GL1's regulatory roles in cellular homeostasis and disease pathways, emphasizing its potential as a therapeutic target.