TSHB抗体

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Hela cells using TSHB mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using TSHB mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human pancreas tissues using TSHB mouse mAb with DAB staining.    

  
  

**Background of TSHB Antibodies**

TSHB antibodies target the beta subunit of thyroid-stimulating hormone (TSH), a glycoprotein critical for regulating thyroid function. TSH, produced by the anterior pituitary, comprises an alpha subunit (shared with hormones like LH and FSH) and a unique beta subunit (TSHB) that confers biological specificity. Autoantibodies against TSHB are rare but implicated in thyroid dysfunction.

In autoimmune thyroid diseases (e.g., Graves' disease, Hashimoto's thyroiditis), TSHB antibodies may interfere with TSH-receptor interactions, altering thyroid hormone synthesis. For instance, blocking TSHB antibodies might reduce TSH bioactivity, potentially contributing to hypothyroidism. Conversely, stimulating forms could mimic TSH effects, though such cases are poorly documented compared to TSH receptor antibodies (TRAbs).

TSHB antibodies are detected via immunoassays (e.g., ELISA, radioimmunoassay) but are not routinely tested clinically. Their role remains unclear, though research suggests associations with atypical thyroid pathology or heterogeneous autoimmune responses. Notably, TSHB antibodies may coexist with TRAbs, complicating disease interpretation.

Studies also explore TSHB antibodies in non-thyroid conditions, such as pituitary disorders, where they might affect TSH secretion. However, evidence is limited, emphasizing the need for further research to clarify their diagnostic or prognostic significance. Overall, TSHB antibodies represent a niche area in thyroid autoimmunity, offering insights into complex hormone-antibody interactions.