SK2抗体 新品

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Immunofluorescence analysis of HeLa cells using SK2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    

  
  

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     Flow cytometric analysis of HeLa cells using SK2 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using SK2 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using SK2 mouse mAb with DAB staining.    

  
  

**Background of SK2 Antibody**

The SK2 antibody targets the small conductance calcium-activated potassium channel protein 2 (SK2. KCa2.2), encoded by the *KCNN2* gene. SK2 channels are voltage-independent potassium channels activated by intracellular calcium, playing critical roles in regulating neuronal excitability, synaptic plasticity, and cardiac rhythmicity. They are predominantly expressed in the brain, particularly in regions like the hippocampus, cortex, and cerebellum, where they modulate afterhyperpolarization currents (IAHP) to influence firing patterns and synaptic transmission. Dysregulation of SK2 channels is implicated in neurological disorders, including epilepsy, ataxia, and cognitive deficits, as well as cardiac arrhythmias.

SK2 antibodies are widely used in neuroscience and cardiovascular research to study channel expression, localization, and function. They enable detection via techniques like Western blot, immunohistochemistry, and immunofluorescence. Studies utilizing SK2 antibodies have revealed its interaction with calmodulin for calcium sensing and its role in diseases, such as spinocerebellar ataxia and atrial fibrillation. Additionally, SK2 channels are explored as therapeutic targets, with modulators under investigation for treating cognitive impairment or arrhythmias. The development of specific SK2 antibodies has been pivotal in advancing understanding of its physiological and pathological mechanisms.