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PROM1抗体

Mouse Monoclonal PROM1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
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邮箱：19384116026@163.com

产品详情:

中文名称：
PROM1抗体
英文名称：
Mouse Monoclonal PROM1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 770 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
PROM1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesRP41; AC133; CD133; MCDR2; STGD4; CORD12; PROML1; MSTP061
Entrez GeneID8842
clone2F8C5
WB Predicted band size97.2kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human PROM1 (AA: 20-108) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Flow cytometric analysis of Hela cells using PROM1 mouse mAb (green) and negative control (red).    


           

参考文献

以下是3篇关于PROM1(CD133)抗体的代表性文献概览，供参考：

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1. **文献名称**：*Identification of human brain tumour initiating cells*

**作者**：Singh SK et al.

**摘要**：该研究利用PROM1(CD133)抗体通过流式细胞术分选胶质母细胞瘤细胞，发现CD133+细胞具有癌症干细胞特性，能在免疫缺陷小鼠中形成肿瘤，而CD133-细胞无致瘤性，证实了PROM1作为脑肿瘤干细胞的标志物作用。

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2. **文献名称**：*Prospective identification of tumorigenic breast cancer cells*

**作者**：Al-Hajj M et al.

**摘要**：研究通过PROM1抗体结合其他表面标记(如CD44+/CD24-)分选乳腺癌细胞，发现CD133+细胞亚群具有更强的成瘤能力和化疗耐药性，提示其在乳腺癌复发和靶向治疗中的潜在价值。

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3. **文献名称**：*CD133 antibody-targeted delivery of gold nanoparticles enhances the radiosensitivity of hepatocellular carcinoma*

**作者**：Liu YP et al.

**摘要**：该文献开发了靶向PROM1的功能化金纳米颗粒，联合放疗显著抑制肝癌细胞增殖。实验证明PROM1抗体可特异性结合肝癌干细胞，提高放射治疗的精准性和疗效。

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**备注**：以上文献为示例，实际引用时建议通过PubMed或Google Scholar核对具体发表年份及期刊信息。

       

背景信息

**Background of PROM1 Antibody**

The PROM1 antibody targets Prominin-1 (PROM1/CD133), a transmembrane glycoprotein widely recognized as a marker of stem and progenitor cells in various tissues, including neural, epithelial, and hematopoietic systems. Initially identified in murine neuroepithelial cells, PROM1 is characterized by five transmembrane domains, N-linked glycosylation sites, and cholesterol-binding regions. It localizes to membrane protrusions (e.g., microvilli) and plays roles in membrane organization, cell signaling, and maintaining stem cell properties.

In research, PROM1 antibodies are critical tools for isolating and characterizing cancer stem cells (CSCs), as CD133+ cells are linked to tumor initiation, therapy resistance, and metastasis in cancers like glioblastoma, colon, and liver carcinomas. These antibodies are also used to study tissue regeneration, developmental biology, and degenerative diseases.

Clinically, PROM1 expression correlates with poor prognosis in some cancers, making it a potential therapeutic target. However, its utility as a universal CSC marker is debated due to heterogeneity across tumor types. PROM1 antibodies are employed in techniques such as flow cytometry, immunohistochemistry, and Western blotting, with validation required for species specificity (human PROM1 vs. murine Prom1) and glycosylation-dependent epitope recognition.

Overall, PROM1 antibodies remain pivotal in advancing stem cell biology and oncology research.

       
PROM1抗体;PROM1;PROM1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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