HDAC9抗体

+ +

•  

   

     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

•  

   

     Flow cytometric analysis of Hela cells using HDAC9 mouse mAb (green) and negative control (red).    

  
  

Histone deacetylase 9 (HDAC9) is a class II member of the HDAC family, enzymes that regulate gene expression by removing acetyl groups from lysine residues on histones, leading to chromatin condensation and transcriptional repression. HDAC9 shuttles between the nucleus and cytoplasm, playing roles in development, cardiac function, muscle differentiation, and immune regulation. Dysregulation of HDAC9 is linked to diseases such as cancer, cardiovascular disorders, and neurodegenerative conditions, making it a target for therapeutic research.

HDAC9 antibodies are essential tools for studying its expression, localization, and functional mechanisms. These antibodies enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect HDAC9 in tissues or cultured cells. Specificity varies depending on the antibody's design; some target unique epitopes in HDAC9's N-terminal domain or catalytic region, distinguishing it from other HDAC isoforms. Monoclonal antibodies offer high consistency, while polyclonal versions may detect multiple epitopes, enhancing sensitivity but requiring rigorous validation.

Quality control parameters, including cross-reactivity tests and batch-to-batch reproducibility, are critical for reliable data. HDAC9 antibodies are widely used in basic research to explore its role in epigenetic regulation and disease pathways, as well as in preclinical studies evaluating HDAC inhibitors as potential therapies.