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TERT抗体

Mouse Monoclonal TERT Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

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联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
TERT抗体
英文名称：
Mouse Monoclonal TERT Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 752 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
TERT

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesTP2; TRT; CMM9; EST2; TCS1; hTRT; DKCA2; DKCB4; hEST2; PFBMFT1
Entrez GeneID7015
clone3H2C12
WB Predicted band size127kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TERT (AA: 1029-1132) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Flow cytometric analysis of Hela cells using TERT mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using TERT mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using TERT mouse mAb with DAB staining.    


           

参考文献

以下是关于TERT抗体的3篇参考文献示例(内容为虚构，仅供格式参考)：

1. **文献名称**: "A novel monoclonal antibody targeting TERT for the detection of telomerase activity in cancer cells"

**作者**: Smith A, et al.

**摘要**: 研究开发了一种新型TERT单克隆抗体，通过免疫组化验证其在多种癌细胞系中的特异性结合，证实其可用于检测端粒酶活性，为癌症诊断提供潜在工具。

2. **文献名称**: "TERT antibody-based liquid biopsy for early diagnosis of hepatocellular carcinoma"

**作者**: Chen L, et al.

**摘要**: 利用TERT抗体富集血液中游离的TERT蛋白片段，结合ELISA技术开发无创检测方法，在肝癌早期患者中敏感性和特异性分别达到85%和92%。

3. **文献名称**: "Prognostic value of cytoplasmic TERT expression in glioblastoma multiforme"

**作者**: Müller S, et al.

**摘要**: 通过TERT抗体的免疫荧光分析，发现胶质母细胞瘤细胞质中TERT异常定位与患者总生存期缩短显著相关，提示其作为预后标志物的潜力。

注：以上文献信息为模拟生成，实际引用需查询真实数据库(如PubMed)。建议通过关键词“TERT antibody”或“anti-TERT”在学术平台检索最新研究。

       

背景信息

**Background of TERT Antibodies**

Telomerase reverse transcriptase (TERT) is the catalytic subunit of telomerase, an enzyme critical for maintaining telomere length and enabling cellular immortalization. TERT expression is typically restricted to germline and stem cells but is reactivated in ~90% of human cancers, contributing to unchecked proliferation and tumorigenesis. TERT antibodies are essential tools for detecting TERT protein expression, localization, and post-translational modifications in research and diagnostic settings.

These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study TERT's role in cancer progression, aging, and telomere-related disorders. For example, TERT overexpression in cancers such as melanoma, glioblastoma, and hepatocellular carcinoma correlates with poor prognosis, making TERT a potential therapeutic target. Antibodies also aid in exploring TERT's non-canonical roles, including its interaction with signaling pathways like Wnt and NF-κB.

Challenges persist in ensuring antibody specificity due to TERT's low abundance in somatic cells and homology with other reverse transcriptases. Validation using TERT-knockout cell lines or siRNA controls is critical. Commercial TERT antibodies vary in performance across applications, necessitating careful selection. Despite these challenges, TERT antibodies remain indispensable for advancing research into cancer mechanisms, aging, and regenerative medicine.

       
TERT抗体;TERT;TERT Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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