CBX1抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CBX1 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using CBX1 mouse mAb with DAB staining.    

  
  

The CBX1 antibody is a tool used to study the Chromobox homolog 1 (CBX1) protein, a member of the Polycomb group (PcG) family. CBX1. also known as HP1β (Heterochromatin Protein 1β), plays a critical role in epigenetic regulation by mediating gene silencing through chromatin modification. It is a key component of heterochromatin, facilitating the formation of compact chromatin structures by binding to trimethylated lysine 9 on histone H3 (H3K9me3), a hallmark of transcriptionally repressive heterochromatin. This interaction is essential for maintaining genomic stability, telomere integrity, and proper chromosome segregation during cell division.

CBX1 antibodies are widely employed in research to investigate its localization, expression, and function in cellular processes such as differentiation, senescence, and cancer. They are used in techniques like Western blotting, immunofluorescence, chromatin immunoprecipitation (ChIP), and immunohistochemistry. Dysregulation of CBX1 has been linked to various cancers, where its overexpression or mislocalization may contribute to tumor progression by silencing tumor suppressor genes.

These antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown to ensure accurate detection. Researchers select CBX1 antibodies based on target epitopes, species reactivity (e.g., human, mouse), and application compatibility. Understanding CBX1's role through these antibodies provides insights into epigenetic mechanisms and potential therapeutic targets for diseases linked to chromatin dysfunction.