KCND2抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Flow cytometric analysis of Hela cells using KCND2 mouse mAb (green) and negative control (red).    

  
  

The KCND2 antibody targets the Kv4.2 protein, a voltage-gated potassium channel encoded by the KCND2 gene. Kv4.2 is a key component of the Shal family, forming tetrameric channels that regulate A-type potassium currents (IA), which shape neuronal excitability and action potential repolarization. Predominantly expressed in the brain, Kv4.2 is enriched in the hippocampus, cerebellum, and basal ganglia, where it modulates synaptic plasticity, dendritic signal integration, and learning/memory processes. Its activity is tightly regulated by auxiliary subunits like KChIPs and dipeptidyl peptidase-like proteins, which influence trafficking and gating kinetics.

KCND2 antibodies are critical tools for studying Kv4.2's expression patterns, subcellular localization, and functional roles in physiological and pathological contexts. Dysregulation of Kv4.2 has been linked to neurological disorders, including epilepsy, autism spectrum disorders, and Alzheimer’s disease. Researchers employ these antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate protein levels in disease models or assess post-translational modifications. Specificity validation, often via knockout controls, ensures reliable detection. Understanding Kv4.2’s role through antibody-based studies may inform therapeutic strategies targeting excitability disorders. (Word count: 199)