RAP1GAP抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Flow cytometric analysis of A431 cells using RAP1GAP mouse mAb (green) and negative control (red).    

  
  

**Background of RAP1GAP Antibody**

RAP1GAP (RAP1 GTPase-activating protein) is a member of the GTPase-activating protein (GAP) family that regulates RAP1 signaling, a small GTPase in the Ras superfamily. RAP1 plays critical roles in cell adhesion, proliferation, and differentiation by cycling between active GTP-bound and inactive GDP-bound states. RAP1GAP accelerates the hydrolysis of GTP to GDP, thereby negatively modulating RAP1 activity and downstream signaling pathways.

The RAP1GAP antibody is a tool designed to detect and quantify RAP1GAP protein expression in research applications. Structurally, RAP1GAP contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic GAP domain, which binds RAP1 to inactivate it. Studies have linked RAP1GAP dysregulation to various cancers, including breast, thyroid, and pancreatic cancers, where its downregulation is associated with tumor progression, metastasis, and poor prognosis. Its role in suppressing integrin- or cadherin-mediated signaling highlights its potential as a therapeutic target or biomarker.

RAP1GAP antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore RAP1GAP’s expression patterns, interactions, and functional mechanisms. These antibodies aid in elucidating how RAP1GAP influences cellular processes, such as cytoskeletal organization and cell-matrix adhesion, providing insights into its involvement in both physiological and pathological contexts.