SSTR3抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Western blot analysis using SSTR3 mouse mAb against Hela (1), PANC-1 (2), PC-12 (3),SK-N-SH (4), U937 (5) and HepG2 (6) cell lysate.    

  
  

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     Flow cytometric analysis of Hela cells using SSTR3 mouse mAb (green) and negative control (red).    

  
  

The somatostatin receptor subtype 3 (SSTR3) is a G protein-coupled receptor (GPCR) that binds somatostatin (SST), a neuropeptide regulating hormone secretion, cell proliferation, and neurotransmission. SSTR3. encoded by the *SSTR3* gene, is one of five known SST receptor subtypes (SSTR1-5) with distinct tissue distribution and signaling pathways. It is widely expressed in the central nervous system, pancreas, gastrointestinal tract, and certain endocrine tissues. Upon SST binding, SSTR3 primarily inhibits adenylyl cyclase via Gαi/o proteins, reducing intracellular cAMP levels, and may also modulate ion channels or MAPK pathways.

SSTR3 has gained attention for its role in neuroendocrine tumors (NETs), pituitary adenomas, and inflammatory conditions, where it is often overexpressed. Antibodies targeting SSTR3 are critical tools for research and diagnostics, enabling immunohistochemical detection of receptor expression in tissues. They also support therapeutic development, such as SST analog-based therapies or radiopharmaceuticals for targeted cancer imaging (e.g., PET scans) and treatment. Monoclonal SSTR3 antibodies are commonly used in Western blotting, immunofluorescence, and flow cytometry to study receptor localization, expression dynamics, and signaling mechanisms. Recent studies explore its potential in neurodegenerative diseases and metabolic disorders, highlighting its broader physiological relevance. However, challenges remain in specificity due to structural homology among SSTR subtypes, necessitating rigorous antibody validation. Overall, SSTR3 antibodies serve as vital reagents for unraveling receptor biology and advancing precision medicine approaches.