TERF2抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using TERF2 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using TERF2 mouse mAb with DAB staining.    

  
  

TERF2 (Telomeric Repeat-binding Factor 2), also known as TRF2. is a key component of the shelterin complex that plays a critical role in maintaining telomere integrity and genomic stability. It binds to double-stranded telomeric DNA repeats (TTAGGG)n, facilitating the formation of T-loop structures to protect chromosome ends from being recognized as DNA damage sites. TERF2 prevents inappropriate activation of DNA repair pathways, such as non-homologous end joining (NHEJ), thereby safeguarding against chromosomal fusions, senescence, or apoptosis. Dysregulation of TERF2 is implicated in aging, cancer, and telomere-related disorders.

TERF2 antibodies are essential tools for studying telomere biology. They enable the detection, localization, and quantification of TERF2 protein in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). These antibodies help researchers investigate TERF2's interactions with other shelterin proteins (e.g., POT1. RAP1), its role in telomere length regulation, and its involvement in diseases. Commercially available TERF2 antibodies vary in host species (rabbit, mouse), clonality (monoclonal/polyclonal), and epitope specificity, requiring validation for specific experimental conditions. Recent studies also explore TERF2's non-telomeric roles in mitochondrial function and inflammatory signaling, expanding its relevance beyond classical telomere maintenance.