GABBR2抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Immunofluorescence analysis of Hela cells using GABBR2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Secondary antibody from Fisher (Cat#: 35503)    

  
  

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     Immunohistochemical analysis of paraffin-embedded human cerebellum tissues using GABBR2 mouse mAb with DAB staining.    

  
  

The GABBR2 antibody is a crucial tool for studying the GABA B receptor subunit 2 (GABBR2), a component of the GABA B receptor, a class C G-protein-coupled receptor (GPCR) central to inhibitory neurotransmission. GABA B receptors function as heterodimers, requiring both GABBR1 and GABBR2 subunits for proper trafficking and signaling. GABBR2 plays a key role in coupling receptor activation to downstream effectors, such as G proteins and ion channels, modulating synaptic transmission, neuronal excitability, and long-term plasticity. It is widely expressed in the central and peripheral nervous systems, influencing processes like anxiety, pain perception, and cognitive function.

Antibodies targeting GABBR2 enable researchers to investigate its expression, localization, and interactions in tissues and cell models. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study receptor distribution under physiological and pathological conditions. Dysregulation of GABBR2 has been implicated in neurological and psychiatric disorders, including epilepsy, schizophrenia, and addiction, making it a potential therapeutic target.

Commercial GABBR2 antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments. Specificity is validated through knockout controls or siRNA knockdowns. Researchers must verify antibody performance in their experimental systems due to potential cross-reactivity with related proteins or tissue-specific isoforms. These tools advance our understanding of GABA B receptor biology and its role in disease mechanisms.