SERPINA7抗体

SERPINA7. also known as thyroxine-binding globulin (TBG), is a liver-derived glycoprotein belonging to the serine protease inhibitor (SERPIN) superfamily. It serves as the primary transport protein for thyroid hormones (T3 and T4) in the bloodstream, regulating their bioavailability and distribution. SERPINA7 antibodies are tools used to detect and quantify this protein in research or clinical diagnostics. These antibodies are critical for studying TBG-related disorders, such as hereditary TBG deficiencies or excess, which are often linked to mutations in the *SERPINA7* gene located on the X chromosome. Autoantibodies against TBG are rare but may interfere with thyroid hormone assays, leading to diagnostic challenges. In research, SERPINA7 antibodies aid in investigating thyroid hormone metabolism, liver function, and the role of TBG in conditions like hypothyroidism or hyperthyroidism. They are commonly employed in techniques like ELISA, Western blotting, or immunohistochemistry to assess TBG expression in serum or tissue samples. Understanding SERPINA7 antibody specificity and cross-reactivity is essential for accurate interpretation of thyroid function tests and advancing studies on hormone transport mechanisms.