THY1抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Western blot analysis using THY1 mouse mAb against T47D (1), HepG2 (2) and PC-12 (3) cell lysate.    

  
  

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     Immunofluorescence analysis of Hela cells using THY1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using THY1 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human cerebellum tissues using THY1 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded Rat spleen using THY1 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded Rat kidney using THY1 mouse mAb with DAB staining.    

  
  

THY1 antibody targets the THY1 glycoprotein, also known as CD90. a glycosylphosphatidylinositol (GPI)-anchored cell surface protein belonging to the immunoglobulin superfamily. First identified in murine thymocytes in the 1970s, THY1 is evolutionarily conserved and expressed in various cell types, including neurons, fibroblasts, certain stem cells, and activated endothelial cells. Its expression varies across species and tissues; for example, it is abundant in rodent neurons but predominantly found in human fibroblasts. THY1 is implicated in cell adhesion, migration, signaling, and interactions with extracellular matrix components, though its precise biological roles remain under investigation.

In research, THY1 antibodies are widely used as markers to identify and isolate specific cell populations. In neuroscience, they help map neuronal circuits by labeling surface proteins. In immunology and stem cell studies, they assist in characterizing T-cell subsets or mesenchymal stem cells. Function-blocking THY1 antibodies are employed to study its role in processes like fibrosis, cancer metastasis, and immune regulation. Dysregulated THY1 expression has been linked to diseases such as pulmonary fibrosis, glioblastoma, and chronic inflammation, making it a potential therapeutic target. However, species- and tissue-specific expression patterns necessitate careful antibody selection for experimental accuracy.