PLIN2抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Immunohistochemical analysis of paraffin-embedded human liver cancer tissues using PLIN2 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using PLIN2 mouse mAb with DAB staining.    

  
  

Perilipin-2 (PLIN2), also known as adipose differentiation-related protein (ADRP), is a lipid droplet-associated protein belonging to the perilipin family. It plays a critical role in lipid storage and metabolism by stabilizing lipid droplets and regulating intracellular lipolysis. PLIN2 is expressed in various tissues, including adipose tissue, liver, and macrophages, and its expression is upregulated under conditions of lipid overload, such as obesity or fatty liver disease. Research into PLIN2 has focused on its involvement in metabolic disorders, including hepatic steatosis, atherosclerosis, and insulin resistance.

PLIN2 antibodies are essential tools for studying the protein's expression, localization, and function in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect PLIN2 in cell lines, tissue samples, or animal models. Many commercially available PLIN2 antibodies are raised against specific epitopes of human or mouse PLIN2. with cross-reactivity validated across species like rat or primate. Researchers often employ PLIN2 antibodies to investigate lipid droplet dynamics, metabolic pathways, or therapeutic targets in diseases linked to lipid dysregulation. Proper validation through knockout controls or siRNA experiments is crucial to ensure antibody specificity, given the structural similarities among perilipin family members.