ONECUT3抗体

The ONECUT3 antibody targets the ONECUT3 protein (also known as HNF6γ or OC-3), a member of the ONECUT transcription factor family characterized by a single cut-like DNA-binding domain. ONECUT3 plays critical roles in embryonic development, tissue differentiation, and metabolic regulation, particularly in organs like the liver, pancreas, and nervous system. It regulates gene networks involved in cell fate determination, organogenesis, and maintenance of specialized cellular functions. Antibodies against ONECUT3 are widely used in research to study its expression patterns, subcellular localization, and functional interactions via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These tools have revealed ONECUT3's involvement in diseases, including cancers (e.g., hepatocellular carcinoma, neuroendocrine tumors) where its dysregulation correlates with tumor progression. Most ONECUT3 antibodies are raised in rabbits or mice, often targeting specific epitopes within its C-terminal or N-terminal regions. Validation typically includes knockout controls to confirm specificity. As ONECUT3's role in cellular plasticity and disease mechanisms gains attention, its antibodies remain vital for exploring developmental biology, metabolic disorders, and oncogenic pathways.