TUBB2A抗体

The TUBB2A antibody is a tool used to detect tubulin beta 2A class IIa (TUBB2A), a protein encoded by the *TUBB2A* gene. TUBB2A is a member of the β-tubulin family, which forms microtubules—dynamic cytoskeletal structures critical for cell division, intracellular transport, and neuronal development. Mutations in *TUBB2A* are associated with neurodevelopmental disorders, including cortical malformations (e.g., polymicrogyria) and epilepsy, highlighting its role in brain development. TUBB2A antibodies are widely employed in research to study protein expression, localization, and dysfunction in disease models. They are used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to analyze tissue-specific distribution, particularly in neuronal and glial cells. Commercial TUBB2A antibodies vary in clonality (monoclonal/polyclonal), species reactivity (human, mouse, rat), and applications, necessitating validation for specificity via knockout controls. Researchers also utilize these antibodies to explore cancer biology, as tubulin isoforms may influence drug resistance or tumor progression. However, cross-reactivity with other β-tubulin isoforms (e.g., TUBB2B, TUBB3) is a potential limitation, requiring careful experimental design. Overall, TUBB2A antibodies serve as essential reagents for elucidating microtubule-related mechanisms in health and disease.