FZD5抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Western blot analysis using FZD5 mouse mAb against A549 (1), and PC-3 (2) cell lysate.    

  
  

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     Flow cytometric analysis of HepG2 cells using FZD5 mouse mAb (green) and negative control (red).    

  
  

FZD5 (Frizzled-5) is a member of the Frizzled family of G protein-coupled receptors that primarily act as receptors for Wnt signaling molecules. These receptors play critical roles in embryonic development, tissue homeostasis, and stem cell regulation by mediating both canonical (β-catenin-dependent) and non-canonical Wnt pathways. FZD5 specifically binds Wnt ligands like Wnt5a and Wnt11. influencing processes such as cell polarity, proliferation, and differentiation. Dysregulation of FZD5 is implicated in various cancers, including colorectal, breast, and gastric cancers, where it often promotes tumor progression, metastasis, and drug resistance.

FZD5 antibodies are immunological tools designed to detect or inhibit FZD5 protein expression. They are widely used in research to study Wnt signaling mechanisms, assess FZD5 expression patterns in normal vs. diseased tissues (e.g., via Western blot, immunohistochemistry, or flow cytometry), and explore therapeutic targeting. Monoclonal FZD5 antibodies, in particular, are valued for their specificity in blocking receptor-ligand interactions, making them potential candidates for anticancer therapies. Challenges in antibody development include minimizing cross-reactivity with other Frizzled family members due to structural similarities. Recent studies also highlight FZD5's role in metabolic diseases and regenerative medicine, broadening its biomedical relevance.