基本信息 产品详情 公司简介 推荐产品
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
网站主页 化工产品目录 生物化工 抗体 一抗 其他一抗 ANXA1 Antibody ANXA1抗体
  • ANXA1抗体
  • ANXA1抗体
  • ANXA1抗体

1/3

ANXA1抗体

Mouse Monoclonal ANXA1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-10

湖北瑞和宁生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：19384116026@163.com

产品详情:

中文名称：
ANXA1抗体
英文名称：
Mouse Monoclonal ANXA1 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 545 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
ANXA1

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Monkey
IF咨询技术 Human,Mouse,Monkey
IHC1/200 - 1/1000 Human,Mouse,Monkey
ICC技术咨询 Human,Mouse,Monkey
FCM咨询技术 Human,Mouse,Monkey
Elisa1/10000 Human,Mouse,Monkey
   

产品详情

AliasesANX1; LPC1
Entrez GeneID301
clone2F1
WB Predicted band size38.7kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Monkey
ImmunogenPurified recombinant fragment of human ANXA1 (AA: 144-248 ) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

  •  

     

       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


  •  

     

       Western blot analysis using ANXA1 mouse mAb against Hela (1), A549 (2), K562 (3), NIH3T3 (4), C6 (5), and COS7 (6) cell lysate.    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using ANXA1 mouse mAb with DAB staining.    


  •  

     

       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using ANXA1 mouse mAb with DAB staining.    


           

参考文献

以下是关于ANXA1抗体的3条模拟参考文献示例，包含文献名称、作者及摘要概括：

---

1. **文献名称**: *"ANXA1 Antibody Attenuates Neutrophil Migration in Acute Lung Injury via FPR2 Signaling"*

**作者**: Zhang et al., 2021

**摘要**: 本研究通过ANXA1抗体阻断实验，发现ANXA1通过甲酰肽受体2(FPR2)调控中性粒细胞迁移，减轻小鼠急性肺损伤模型的炎症反应，提示其作为潜在抗炎治疗靶点。

---

2. **文献名称**: *"Targeting ANXA1 with Monoclonal Antibodies Suppresses Metastasis in Triple-Negative Breast Cancer"*

**作者**: Patel et al., 2019

**摘要**: 作者开发了一种靶向ANXA1的单克隆抗体，证明其能显著抑制三阴性乳腺癌细胞的侵袭和体内转移，机制涉及EGFR信号通路的下调。

---

3. **文献名称**: *"ANXA1 Antibody-Based Detection Reveals Its Role in Glucocorticoid-Regulated Apoptosis"*

**作者**: Rossi et al., 2017

**摘要**: 通过ANXA1特异性抗体检测，发现糖皮质激素诱导的细胞凋亡依赖于ANXA1的膜易位，该过程在慢性炎症疾病中具有调控潜力。

---

以上为模拟文献，实际引用时需核实真实来源。

       

背景信息

ANXA1 (Annexin A1) is a calcium-dependent phospholipid-binding protein belonging to the annexin superfamily, widely recognized for its role in regulating inflammation, cellular signaling, and membrane repair. Initially identified as a glucocorticoid-inducible protein, ANXA1 modulates anti-inflammatory responses by inhibiting phospholipase A2 and neutrophil migration, while also influencing cell proliferation, apoptosis, and differentiation. It is expressed in various tissues, including immune cells, epithelial cells, and certain cancer cells, where its dysregulation has been linked to pathological conditions such as cancer, autoimmune disorders, and neurodegenerative diseases.

ANXA1 antibodies are essential tools for detecting the protein’s expression, localization, and functional interactions in research. These antibodies are developed using immunogens derived from specific regions of ANXA1. such as its unique N-terminal domain or conserved C-terminal core. They enable applications like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. In cancer research, ANXA1 antibodies help assess its dual role as a tumor suppressor or promoter, depending on context, with implications for breast cancer, glioblastoma, and prostate cancer. Specificity validation via knockout controls or blocking peptides is critical due to potential cross-reactivity with other annexins or post-translational modifications. Commercial ANXA1 antibodies vary in host species (e.g., mouse, rabbit), clonality (monoclonal/polyoclonal), and conjugate tags, allowing flexibility for experimental design. Their utility extends to exploring ANXA1’s therapeutic potential, including targeted anti-inflammatory drug development.

       
ANXA1抗体;ANXA1;ANXA1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

ANXA1抗体相关厂家报价

内容声明
official 进入官方账号
拨打电话 立即询价