PPM1A抗体

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     Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    

  
  

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     Western blot analysis using PPM1A mouse mAb against Jurkat (1), Jurkat (2), A431 (3), HeLa (4), HEK293 (5), Raji (6), MCF-7 (7), and COS7 (8) cell lysate.    

  
  

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     Flow cytometric analysis of HeLa cells using PPM1A mouse mAb (green) and negative control (red).    

  
  

The PPM1A antibody is a crucial tool for studying the protein phosphatase magnesium-dependent 1A (PPM1A), a member of the PP2C family of serine/threonine phosphatases. PPM1A plays a pivotal role in regulating cellular stress responses, cell cycle progression, and apoptosis by dephosphoryulating key signaling molecules. It is implicated in modulating pathways such as TGF-β, p38 MAPK, and NF-κB, impacting processes like inflammation, cancer progression, and metabolic disorders. Dysregulation of PPM1A has been linked to diseases including hepatocellular carcinoma, neurodegenerative conditions, and diabetes.

The PPM1A antibody enables the detection and quantification of PPM1A expression in various experimental applications, including Western blotting, immunohistochemistry, immunoprecipitation, and immunofluorescence. Researchers rely on its specificity to investigate PPM1A’s subcellular localization, interaction partners, and expression patterns across tissues or under pathological conditions. High-quality PPM1A antibodies are typically validated using knockout controls or siRNA-mediated knockdown to confirm target specificity.

Available as monoclonal or polyclonal versions from diverse host species (e.g., rabbit, mouse), these antibodies are essential for elucidating PPM1A’s regulatory mechanisms in cellular homeostasis and disease, offering potential insights for therapeutic targeting. Proper validation ensures reliability in both basic research and translational studies.